Плектин
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Плектин (англ. Plectin) – білок, який кодується геном PLEC, розташованим у людей на короткому плечі 8-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 4 684 амінокислот, а молекулярна маса — 531 791[5].
Послідовність амінокислот
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MVAGMLMPRD | QLRAIYEVLF | REGVMVAKKD | RRPRSLHPHV | PGVTNLQVMR | ||||
AMASLRARGL | VRETFAWCHF | YWYLTNEGIA | HLRQYLHLPP | EIVPASLQRV | ||||
RRPVAMVMPA | RRTPHVQAVQ | GPLGSPPKRG | PLPTEEQRVY | RRKELEEVSP | ||||
ETPVVPATTQ | RTLARPGPEP | APATDERDRV | QKKTFTKWVN | KHLIKAQRHI | ||||
SDLYEDLRDG | HNLISLLEVL | SGDSLPREKG | RMRFHKLQNV | QIALDYLRHR | ||||
QVKLVNIRND | DIADGNPKLT | LGLIWTIILH | FQISDIQVSG | QSEDMTAKEK | ||||
LLLWSQRMVE | GYQGLRCDNF | TSSWRDGRLF | NAIIHRHKPL | LIDMNKVYRQ | ||||
TNLENLDQAF | SVAERDLGVT | RLLDPEDVDV | PQPDEKSIIT | YVSSLYDAMP | ||||
RVPDVQDGVR | ANELQLRWQE | YRELVLLLLQ | WMRHHTAAFE | ERRFPSSFEE | ||||
IEILWSQFLK | FKEMELPAKE | ADKNRSKGIY | QSLEGAVQAG | QLKVPPGYHP | ||||
LDVEKEWGKL | HVAILEREKQ | LRSEFERLEC | LQRIVTKLQM | EAGLCEEQLN | ||||
QADALLQSDV | RLLAAGKVPQ | RAGEVERDLD | KADSMIRLLF | NDVQTLKDGR | ||||
HPQGEQMYRR | VYRLHERLVA | IRTEYNLRLK | AGVAAPATQV | AQVTLQSVQR | ||||
RPELEDSTLR | YLQDLLAWVE | ENQHRVDGAE | WGVDLPSVEA | QLGSHRGLHQ | ||||
SIEEFRAKIE | RARSDEGQLS | PATRGAYRDC | LGRLDLQYAK | LLNSSKARLR | ||||
SLESLHSFVA | AATKELMWLN | EKEEEEVGFD | WSDRNTNMTA | KKESYSALMR | ||||
ELELKEKKIK | ELQNAGDRLL | REDHPARPTV | ESFQAALQTQ | WSWMLQLCCC | ||||
IEAHLKENAA | YFQFFSDVRE | AEGQLQKLQE | ALRRKYSCDR | SATVTRLEDL | ||||
LQDAQDEKEQ | LNEYKGHLSG | LAKRAKAVVQ | LKPRHPAHPM | RGRLPLLAVC | ||||
DYKQVEVTVH | KGDECQLVGP | AQPSHWKVLS | SSGSEAAVPS | VCFLVPPPNQ | ||||
EAQEAVTRLE | AQHQALVTLW | HQLHVDMKSL | LAWQSLRRDV | QLIRSWSLAT | ||||
FRTLKPEEQR | QALHSLELHY | QAFLRDSQDA | GGFGPEDRLM | AEREYGSCSH | ||||
HYQQLLQSLE | QGAQEESRCQ | RCISELKDIR | LQLEACETRT | VHRLRLPLDK | ||||
EPARECAQRI | AEQQKAQAEV | EGLGKGVARL | SAEAEKVLAL | PEPSPAAPTL | ||||
RSELELTLGK | LEQVRSLSAI | YLEKLKTISL | VIRGTQGAEE | VLRAHEEQLK | ||||
EAQAVPATLP | ELEATKASLK | KLRAQAEAQQ | PTFDALRDEL | RGAQEVGERL | ||||
QQRHGERDVE | VERWRERVAQ | LLERWQAVLA | QTDVRQRELE | QLGRQLRYYR | ||||
ESADPLGAWL | QDARRRQEQI | QAMPLADSQA | VREQLRQEQA | LLEEIERHGE | ||||
KVEECQRFAK | QYINAIKDYE | LQLVTYKAQL | EPVASPAKKP | KVQSGSESVI | ||||
QEYVDLRTHY | SELTTLTSQY | IKFISETLRR | MEEEERLAEQ | QRAEERERLA | ||||
EVEAALEKQR | QLAEAHAQAK | AQAEREAKEL | QQRMQEEVVR | REEAAVDAQQ | ||||
QKRSIQEELQ | QLRQSSEAEI | QAKARQAEAA | ERSRLRIEEE | IRVVRLQLEA | ||||
TERQRGGAEG | ELQALRARAE | EAEAQKRQAQ | EEAERLRRQV | QDESQRKRQA | ||||
EVELASRVKA | EAEAAREKQR | ALQALEELRL | QAEEAERRLR | QAEVERARQV | ||||
QVALETAQRS | AEAELQSKRA | SFAEKTAQLE | RSLQEEHVAV | AQLREEAERR | ||||
AQQQAEAERA | REEAERELER | WQLKANEALR | LRLQAEEVAQ | QKSLAQAEAE | ||||
KQKEEAEREA | RRRGKAEEQA | VRQRELAEQE | LEKQRQLAEG | TAQQRLAAEQ | ||||
ELIRLRAETE | QGEQQRQLLE | EELARLQREA | AAATQKRQEL | EAELAKVRAE | ||||
MEVLLASKAR | AEEESRSTSE | KSKQRLEAEA | GRFRELAEEA | ARLRALAEEA | ||||
KRQRQLAEED | AARQRAEAER | VLAEKLAAIG | EATRLKTEAE | IALKEKEAEN | ||||
ERLRRLAEDE | AFQRRRLEEQ | AAQHKADIEE | RLAQLRKASD | SELERQKGLV | ||||
EDTLRQRRQV | EEEILALKAS | FEKAAAGKAE | LELELGRIRS | NAEDTLRSKE | ||||
QAELEAARQR | QLAAEEERRR | REAEERVQKS | LAAEEEAARQ | RKAALEEVER | ||||
LKAKVEEARR | LRERAEQESA | RQLQLAQEAA | QKRLQAEEKA | HAFAVQQKEQ | ||||
ELQQTLQQEQ | SVLDQLRGEA | EAARRAAEEA | EEARVQAERE | AAQSRRQVEE | ||||
AERLKQSAEE | QAQARAQAQA | AAEKLRKEAE | QEAARRAQAE | QAALRQKQAA | ||||
DAEMEKHKKF | AEQTLRQKAQ | VEQELTTLRL | QLEETDHQKN | LLDEELQRLK | ||||
AEATEAARQR | SQVEEELFSV | RVQMEELSKL | KARIEAENRA | LILRDKDNTQ | ||||
RFLQEEAEKM | KQVAEEAARL | SVAAQEAARL | RQLAEEDLAQ | QRALAEKMLK | ||||
EKMQAVQEAT | RLKAEAELLQ | QQKELAQEQA | RRLQEDKEQM | AQQLAEETQG | ||||
FQRTLEAERQ | RQLEMSAEAE | RLKLRVAEMS | RAQARAEEDA | QRFRKQAEEI | ||||
GEKLHRTELA | TQEKVTLVQT | LEIQRQQSDH | DAERLREAIA | ELEREKEKLQ | ||||
QEAKLLQLKS | EEMQTVQQEQ | LLQETQALQQ | SFLSEKDSLL | QRERFIEQEK | ||||
AKLEQLFQDE | VAKAQQLREE | QQRQQQQMEQ | ERQRLVASME | EARRRQHEAE | ||||
EGVRRKQEEL | QQLEQQRRQQ | EELLAEENQR | LREQLQLLEE | QHRAALAHSE | ||||
EVTASQVAAT | KTLPNGRDAL | DGPAAEAEPE | HSFDGLRRKV | SAQRLQEAGI | ||||
LSAEELQRLA | QGHTTVDELA | RREDVRHYLQ | GRSSIAGLLL | KATNEKLSVY | ||||
AALQRQLLSP | GTALILLEAQ | AASGFLLDPV | RNRRLTVNEA | VKEGVVGPEL | ||||
HHKLLSAERA | VTGYKDPYTG | QQISLFQAMQ | KGLIVREHGI | RLLEAQIATG | ||||
GVIDPVHSHR | VPVDVAYRRG | YFDEEMNRVL | ADPSDDTKGF | FDPNTHENLT | ||||
YLQLLERCVE | DPETGLCLLP | LTDKAAKGGE | LVYTDSEARD | VFEKATVSAP | ||||
FGKFQGKTVT | IWEIINSEYF | TAEQRRDLLR | QFRTGRITVE | KIIKIIITVV | ||||
EEQEQKGRLC | FEGLRSLVPA | AELLESRVID | RELYQQLQRG | ERSVRDVAEV | ||||
DTVRRALRGA | NVIAGVWLEE | AGQKLSIYNA | LKKDLLPSDM | AVALLEAQAG | ||||
TGHIIDPATS | ARLTVDEAVR | AGLVGPEFHE | KLLSAEKAVT | GYRDPYTGQS | ||||
VSLFQALKKG | LIPREQGLRL | LDAQLSTGGI | VDPSKSHRVP | LDVACARGCL | ||||
DEETSRALSA | PRADAKAYSD | PSTGEPATYG | ELQQRCRPDQ | LTGLSLLPLS | ||||
EKAARARQEE | LYSELQARET | FEKTPVEVPV | GGFKGRTVTV | WELISSEYFT | ||||
AEQRQELLRQ | FRTGKVTVEK | VIKILITIVE | EVETLRQERL | SFSGLRAPVP | ||||
ASELLASGVL | SRAQFEQLKD | GKTTVKDLSE | LGSVRTLLQG | SGCLAGIYLE | ||||
DTKEKVSIYE | AMRRGLLRAT | TAALLLEAQA | ATGFLVDPVR | NQRLYVHEAV | ||||
KAGVVGPELH | EQLLSAEKAV | TGYRDPYSGS | TISLFQAMQK | GLVLRQHGIR | ||||
LLEAQIATGG | IIDPVHSHRV | PVDVAYQRGY | FSEEMNRVLA | DPSDDTKGFF | ||||
DPNTHENLTY | RQLLERCVED | PETGLRLLPL | KGAEKAEVVE | TTQVYTEEET | ||||
RRAFEETQID | IPGGGSHGGS | TMSLWEVMQS | DLIPEEQRAQ | LMADFQAGRV | ||||
TKERMIIIII | EIIEKTEIIR | QQGLASYDYV | RRRLTAEDLF | EARIISLETY | ||||
NLLREGTRSL | REALEAESAW | CYLYGTGSVA | GVYLPGSRQT | LSIYQALKKG | ||||
LLSAEVARLL | LEAQAATGFL | LDPVKGERLT | VDEAVRKGLV | GPELHDRLLS | ||||
AERAVTGYRD | PYTEQTISLF | QAMKKELIPT | EEALRLLDAQ | LATGGIVDPR | ||||
LGFHLPLEVA | YQRGYLNKDT | HDQLSEPSEV | RSYVDPSTDE | RLSYTQLLRR | ||||
CRRDDGTGQL | LLPLSDARKL | TFRGLRKQIT | MEELVRSQVM | DEATALQLRE | ||||
GLTSIEEVTK | NLQKFLEGTS | CIAGVFVDAT | KERLSVYQAM | KKGIIRPGTA | ||||
FELLEAQAAT | GYVIDPIKGL | KLTVEEAVRM | GIVGPEFKDK | LLSAERAVTG | ||||
YKDPYSGKLI | SLFQAMKKGL | ILKDHGIRLL | EAQIATGGII | DPEESHRLPV | ||||
EVAYKRGLFD | EEMNEILTDP | SDDTKGFFDP | NTEENLTYLQ | LMERCITDPQ | ||||
TGLCLLPLKE | KKRERKTSSK | SSVRKRRVVI | VDPETGKEMS | VYEAYRKGLI | ||||
DHQTYLELSE | QECEWEEITI | SSSDGVVKSM | IIDRRSGRQY | DIDDAIAKNL | ||||
IDRSALDQYR | AGTLSITEFA | DMLSGNAGGF | RSRSSSVGSS | SSYPISPAVS | ||||
RTQLASWSDP | TEETGPVAGI | LDTETLEKVS | ITEAMHRNLV | DNITGQRLLE | ||||
AQACTGGIID | PSTGERFPVT | DAVNKGLVDK | IMVDRINLAQ | KAFCGFEDPR | ||||
TKTKMSAAQA | LKKGWLYYEA | GQRFLEVQYL | TGGLIEPDTP | GRVPLDEALQ | ||||
RGTVDARTAQ | KLRDVGAYSK | YLTCPKTKLK | ISYKDALDRS | MVEEGTGLRL | ||||
LEAAAQSTKG | YYSPYSVSGS | GSTAGSRTGS | RTGSRAGSRR | GSFDATGSGF | ||||
SMTFSSSSYS | SSGYGRRYAS | GSSASLGGPE | SAVA |
Білок має сайт для зв'язування з молекулою актину. Локалізований у цитоплазмі, цитоскелеті, клітинних контактах.
Література[ред. | ред. код]
- Liu C.-G., Maercker C., Castanon M.J., Hauptmann R., Wiche G. (1996). Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24).. Proc. Natl. Acad. Sci. U.S.A. 93: 4278 — 4283. PubMed DOI:10.1073/pnas.93.9.4278
- Zhang T., Haws P., Wu Q. (2004). Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.. Genome Res. 14: 79 — 89. PubMed DOI:10.1101/gr.1225204
- Koster J., Geerts D., Favre B., Borradori L., Sonnenberg A. (2003). Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.. J. Cell Sci. 116: 387 — 399. PubMed DOI:10.1242/jcs.00241
- Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. (2008). Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.. J. Proteome Res. 7: 5167 — 5176. PubMed DOI:10.1021/pr800500r
- Maiweilidan Y., Klauza I., Kordeli E. (2011). Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C.. Exp. Cell Res. 317: 724 — 736. PubMed DOI:10.1016/j.yexcr.2011.01.002
- Sonnenberg A., Rojas A.M., de Pereda J.M. (2007). The structure of a tandem pair of spectrin repeats of plectin reveals a modular organization of the plakin domain.. J. Mol. Biol. 368: 1379 — 1391. PubMed DOI:10.1016/j.jmb.2007.02.090
Примітки[ред. | ред. код]
- ↑ Захворювання, генетично пов'язані з Плектин переглянути/редагувати посилання на ВікіДаних.
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:9069 (англ.). Процитовано 6 лютого 2017.
- ↑ UniProt, Q15149 (англ.). Процитовано 6 лютого 2017.
Див. також[ред. | ред. код]
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