Матеріал з Вікіпедії — вільної енциклопедії.
IL10
Ідентифікатори
Символи IL10 Зовнішні ІД
OMIM : 124092 MGI: 96537 HomoloGene: 478 GeneCards: IL10
Пов'язані генетичні захворювання
синдром Бехчета , неспецифічний виразковий коліт [1]
Онтологія гена Молекулярна функція
• GO:0001948, GO:0016582 protein binding • growth factor activity • cytokine activity • interleukin-10 receptor binding • protein dimerization activity
Клітинна компонента
• extracellular region • міжклітинний простір
Біологічний процес
• negative regulation of chronic inflammatory response to antigenic stimulus • positive regulation of MHC class II biosynthetic process • negative regulation of endothelial cell apoptotic process • кровотворення • negative regulation of interferon-gamma production • regulation of sensory perception of pain • positive regulation of B cell apoptotic process • negative regulation of chemokine (C-C motif) ligand 5 production • response to inactivity • negative regulation of cytokine activity • negative regulation of interleukin-1 production • cellular response to hepatocyte growth factor stimulus • cellular response to estradiol stimulus • negative regulation of interleukin-6 production • GO:0010260 старіння людини • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • GO:0002719 negative regulation of cytokine production involved in immune response • response to glucocorticoid • cytoplasmic sequestering of NF-kappaB • negative regulation of interleukin-18 production • negative regulation of MHC class II biosynthetic process • response to activity • response to organic substance • response to carbon monoxide • leukocyte chemotaxis • type 2 immune response • negative regulation of myeloid dendritic cell activation • response to insulin • negative regulation of interleukin-8 production • response to lipopolysaccharide • B cell proliferation • negative regulation of T cell proliferation • negative regulation of nitric oxide biosynthetic process • branching involved in labyrinthine layer morphogenesis • defense response to bacterium • regulation of complement-dependent cytotoxicity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • регуляція експресії генів • B cell differentiation • regulation of isotype switching • negative regulation of tumor necrosis factor production • negative regulation of membrane protein ectodomain proteolysis • inflammatory response • cellular response to lipopolysaccharide • negative regulation of B cell proliferation • negative regulation of inflammatory response • GO:0032697 negative regulation of cytokine production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of interleukin-12 production • defense response to protozoan • negative regulation of sensory perception of pain • positive regulation of macrophage activation • liver regeneration • GO:1904739 regulation of synapse organization • positive regulation of endothelial cell proliferation • negative regulation of cell population proliferation • negative regulation of heterotypic cell-cell adhesion • positive regulation of heterotypic cell-cell adhesion • positive regulation of cell cycle • negative regulation of mitotic cell cycle • endothelial cell apoptotic process • regulation of response to wounding • negative regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • interleukin-12-mediated signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of autophagy • cytokine-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of hydrogen peroxide-induced neuron death • positive regulation of sprouting angiogenesis
Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних Ортологи
Види
Людина Миша Entrez Ensembl UniProt RefSeq (мРНК)
RefSeq (білок)
Локус (UCSC)
Хр. 1: 206.77 – 206.77 Mb Хр. 1: 130.95 – 130.95 Mb PubMed search[2] [3] Вікідані
IL10 (англ. Interleukin 10 ) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [4] амінокислот , а молекулярна маса — 20 517[5]
Послідовність амінокислот
10 20 30 40 50 MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR VKTFFQMKDQ LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN QDPDIKAHVN SLGENLKTLR LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ EKGIYKAMSE FDIFINYIEA YMTMKIRN
Кодований геном білок за функцією належить до цитокінів .
Секретований назовні.
Zhang Z., Henzel W.J. (2004). Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci . 13 : 2819—2824. PMID 15340161 DOI :10.1110/ps.04682504 Walter M.R., Nagabhushan T.L. (1995). Crystal structure of interleukin 10 reveals an interferon gamma-like fold. Biochemistry . 34 : 12118—12125. PMID 7547951 DOI :10.1021/bi00038a004 Zdanov A., Schalk-Hihi C., Wlodawer A. (1996). Crystal structure of human interleukin-10 at 1.6-A resolution and a model of a complex with its soluble receptor. Protein Sci . 5 : 1955—1962. PMID 8897595 DOI :10.1002/pro.5560051001 Josephson K., Logsdon N.J., Walter M.R. (2001). Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity . 15 : 35—46. PMID 11485736 DOI :10.1016/S1074-7613(01)00169-8 Yoon S.I., Jones B.C., Logsdon N.J., Walter M.R. (2005). Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure . 13 : 551—564. PMID 15837194 DOI :10.1016/j.str.2005.01.016 Dai W.-J., Jiang H.-C., Pan S.-H. (2001). Cloning, sequencing of human interleukin-10 cDNA and construction of its eukaryotic expression vector. Haerbin Yi Ke Da Xue Xue Bao . 35 : 4—6.
