English: A, Many traditional antidepressants (SSRIs) promote iPlasticity: they induce juvenile-like plasticity in the adult brain (see Castrén, 2005; Umemori et al., 2018). A property of many psychedelics is that they are psychoplastogens: they are exogenously administered therapeutic drugs that promote long-lasting neuroplasticity after a single dose (see Olson, 2018). B, To date, evidence of promoting structural or functional plasticity has been shown for several psychedelics or psychedelic-like drugs (see Olson, 2020; de Vos et al., 2021; Lukasiewicz et al., 2021; Jaster et al., 2021).