Матеріал з Вікіпедії — вільної енциклопедії.
CDKN1A
Ідентифікатори
Символи CDKN1A Зовнішні ІД
OMIM : 116899 MGI: 104556 HomoloGene: 333 GeneCards: CDKN1A
Онтологія гена Молекулярна функція
• зв'язування з іоном металу • GO:0001948, GO:0016582 protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • ubiquitin protein ligase binding • cyclin binding • cyclin-dependent protein kinase activating kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein kinase inhibitor activity • protein kinase binding • GO:0032403 protein-containing complex binding
Клітинна компонента
• цитоплазма • гіалоплазма • cyclin-dependent protein kinase holoenzyme complex • PCNA-p21 complex • perinuclear region of cytoplasm • клітинне ядро • Нуклеоплазма • ядерце • Ядерні тільця • GO:0009327 protein-containing complex
Біологічний процес
• cellular response to extracellular stimulus • signal transduction by p53 class mediator • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cellular response to heat • regulation of cyclin-dependent protein serine/threonine kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of cell death • GO:1904578 response to organic cyclic compound • negative regulation of cyclin-dependent protein serine/threonine kinase activity • stress-induced premature senescence • positive regulation of fibroblast proliferation • replicative senescence • response to hyperoxia • response to corticosterone • cellular response to amino acid starvation • positive regulation of programmed cell death • negative regulation of apoptotic process • response to glucocorticoid • response to arsenic-containing substance • regulation of DNA biosynthetic process • response to organic substance • negative regulation of gene expression • cellular response to DNA damage stimulus • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of cell cycle • intrinsic apoptotic signaling pathway • клітинне старіння • positive regulation of reactive oxygen species metabolic process • cellular response to UV-B • G2/M transition of mitotic cell cycle • positive regulation of B cell proliferation • negative regulation of cell growth • response to organonitrogen compound • animal organ regeneration • regulation of mitotic cell cycle • intestinal epithelial cell maturation • cellular response to ionizing radiation • клітинний цикл • Ras protein signal transduction • negative regulation of phosphorylation • response to toxic substance • response to UV • response to X-ray • negative regulation of cell population proliferation • protein stabilization • positive regulation of cyclin-dependent protein kinase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein kinase activity • cellular response to gamma radiation • negative regulation of cyclin-dependent protein kinase activity • transcription initiation from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • negative regulation of vascular associated smooth muscle cell proliferation
Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних Ортологи
Види
Людина Миша Entrez Ensembl UniProt RefSeq (мРНК)
RefSeq (білок)
Локус (UCSC)
Хр. 6: 36.68 – 36.69 Mb Хр. 17: 29.31 – 29.32 Mb PubMed search[1] [2] Вікідані
CDKN1A (англ. Cyclin dependent kinase inhibitor 1A ) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми.[3] амінокислот , а молекулярна маса — 18 119[4]
Послідовність амінокислот
10 20 30 40 50 MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP
Кодований геном білок за функцією належить до фосфопротеїнів .
Задіяний у таких біологічних процесах, як клітинний цикл , ацетилювання.
Білок має сайт для зв'язування з іонами металів, іоном цинку .
Локалізований у цитоплазмі , ядрі .
Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell . 75 : 805—816. PMID 8242751 DOI :10.1016/0092-8674(93)90499-G Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. (1994). Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res . 211 : 90—98. PMID 8125163 DOI :10.1006/excr.1994.1063 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res . 14 : 2121—2127. 2004. PMID 15489334 DOI :10.1101/gr.2596504 Scott M.T., Morrice N., Ball K.L. (2000). Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. J. Biol. Chem . 275 : 11529—11537. PMID 10753973 DOI :10.1074/jbc.275.15.11529 Coulombe P., Rodier G., Bonneil E., Thibault P., Meloche S. (2004). N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome . Mol. Cell. Biol . 24 : 6140—6150. PMID 15226418 DOI :10.1128/MCB.24.14.6140-6150.2004 Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. (2006). A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol . 24 : 1285—1292. PMID 16964243 DOI :10.1038/nbt1240
