Матеріал з Вікіпедії — вільної енциклопедії.
CSMD2 (англ. CUB and Sushi multiple domains 2 ) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [4] амінокислот , а молекулярна маса — 380 039[5]
Послідовність амінокислот
10 20 30 40 50 MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA NCTWTITAEE QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ LPATIVSAAT TLSLRLISDY AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH AGSENSATWD FPLPSCRADD ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI ALVFIDFQLE DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE RGKRLGSDFR LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC RARMCDAHLR GPSGIITSPN FPIQYDNNAH CVWIITALNP SKVIKLAFEE FDLERGYDTL TVGDGGQDGD QKTVLYILTG TSVPDLIVST NHQMWLLFQT DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG DTLKFECQPA FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG NQLPSSITSS GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG KRFGDSLQLG SSISFLCDEG FLGTQGSETI TCVLKEGSVV WNSAVLRCEA PCGGHLTSPS GTILSPGWPG FYKDALSCAW VIEAQPGYPI KITFDRFKTE VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL LFSTDKSHSD IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC TWIIETSHGK GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA PISAGLYGNF TAQVRFISDF SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR KGLQFGVGDT LTFSCFPGYR LEGTARITCL GGRRRLWSSP LPRCVAECGN SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA RAFELSEGDV LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL LCLSGERRTW DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW TIEAEAGCTI GLHFLVFDTE EVHDVLRIWD GPVESGVLLK ELSGPALPKD LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS TATSCNDPGI PQNGSRSGDS WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT CIAPCGGDLT GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY TENPRESCFD PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL GPDGKPVWNN PRPVCTAPCG GQYVGSDGVV LSPNYPQNYT SGQICLYFVT VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ HSRLLSSLSG SHTGESLPLA TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE PRYGKRLGSD FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL EVFDGADNTV TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE YKTVGLSSCP EPAVPSNGVK TGERYLVNDV VSFQCEPGYA LQGHAHISCM PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL SPGFPGNYPS NMDCSWKIAL PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG SELPSSLLST SHETTVYFHS DHSQNRPGFK LEYQDLTYSH QISSFLRGFD LSELERTNST PPVAASYVWD LDPGCEAYEL QECPDPEPFA NGIVRGAGYN VGQSVTFECL PGYQLTGHPV LTCQHGTNRN WDHPLPKCEV PCGGNITSSN GTVYSPGFPS PYSSSQDCVW LITVPIGHGV RLNLSLLQTE PSGDFITIWD GPQQTAPRLG VFTRSMAKKT VQSSSNQVLL KFHRDAATGG IFAIAFSAYP LTKCPPPTIL PNAEVVTENE EFNIGDIVRY RCLPGFTLVG NEILTCKLGT YLQFEGPPPI CEVHCPTNEL LTDSTGVILS QSYPGSYPQF QTCSWLVRVE PDYNISLTVE YFLSEKQYDE FEIFDGPSGQ SPLLKALSGN YSAPLIVTSS SNSVYLRWSS DHAYNRKGFK IRYSAPYCSL PRAPLHGFIL GQTSTQPGGS IHFGCNAGYR LVGHSMAICT RHPQGYHLWS EAIPLCQALS CGLPEAPKNG MVFGKEYTVG TKAMYSCSEG YHLQAGAEAT AECLDTGLWS NRNVPPQCVP VTCPDVSSIS VEHGRWRLIF ETQYQFQAQL MLICDPGYYY TGQRVIRCQA NGKWSLGDST PTCRIISCGE LPIPPNGHRI GTLSVYGATA IFSCNSGYTL VGSRVRECMA NGLWSGSEVR CLAGHCGTPE PIVNGHINGE NYSYRGSVVY QCNAGFRLIG MSVRICQQDH HWSGKTPFCV LVSCGHPGSP PHSQMSGDSY TVGAVVRYSC IGKRTLVGNS TRMCGLDGHW TGSLPHCSGT SVGVCGDPGI PAHGIRLGDS FDPGTVMRFS CEAGHVLRGS SERTCQANGS WSGSQPECGV ISCGNPGTPS NARVVFSDGL VFSSSIVYEC REGYYATGLL SRHCSVNGTW TGSDPECLVI NCGDPGIPAN GLRLGNDFRY NKTVTYQCVP GYMMESHRVS VLSCTKDRTW NGTKPVCKAL MCKPPPLIPN GKVVGSDFMW GSSVTYACLE GYQLSLPAVF TCEGNGSWTG ELPQCFPVFC GDPGVPSRGR REDRGFSYRS SVSFSCHPPL VLVGSPRRFC QSDGTWSGTQ PSCIDPTLTT CADPGVPQFG IQNNSQGYQV GSTVLFRCQK GYLLQGSTTR TCLPNLTWSG TPPDCVPHHC RQPETPTHAN VGALDLPSMG YTLIYSCQEG FSLKGGSEHR TCKADGSWTG KPPICLEVRP SGRPINTARE PPLTQALIPG DVFAKNSLWK GAYEYQGKKQ PAMLRVTGFQ VANSKVNATM IDHSGVELHL AGTYKKEDFH LLLQVYQITG PVEIFMNKFK DDHWALDGHV SSESSGATFI YQGSVKGQGF GQFGFQRLDL RLLESDPESI GRHFASNSSS VAAAILVPFI ALIIAGFVLY LYKHRRRPKV PFNGYAGHEN TNVRATFENP MYDRNIQPTD IMASEAEFTV STVCTAV
Задіяний у таких біологічних процесах як поліморфізм, альтернативний сплайсинг .
Локалізований у клітинній мембрані , мембрані.
Lau W.L., Scholnick S.B. (2003). Identification of two new members of the CSMD gene family. Genomics . 82 : 412—415. PMID 12906867 DOI :10.1016/S0888-7543(03)00149-6 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res . 14 : 2121—2127. 2004. PMID 15489334 DOI :10.1101/gr.2596504 Nagase T., Kikuno R., Ohara O. (2001). Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. DNA Res . 8 : 179—187. PMID 11572484 DOI :10.1093/dnares/8.4.179
