Матеріал з Вікіпедії — вільної енциклопедії.
FCGBP (англ. Fc fragment of IgG binding protein ) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 19-ї хромосоми. [3] амінокислот , а молекулярна маса — 572 017[4]
Послідовність амінокислот
10 20 30 40 50 MGALWSWWIL WAGATLLWGL TQEASVDLKN TGREEFLTAF LQNYQLAYSK AYPRLLISSL SESPASVSIL SQADNTSKKV TVRPGESVMV NISAKAEMIG SKIFQHAVVI HSDYAISVQA LNAKPDTAEL TLLRPIQALG TEYFVLTPPG TSARNVKEFA VVAGAAGASV SVTLKGSVTF NGKFYPAGDV LRVTLQPYNV AQLQSSVDLS GSKVTASSPV AVLSGHSCAQ KHTTCNHVVE QLLPTSAWGT HYVVPTLASQ SRYDLAFVVA SQATKLTYNH GGITGSRGLQ AGDVVEFEVR PSWPLYLSAN VGIQVLLFGT GAIRNEVTYD PYLVLIPDVA AYCPAYVVKS VPGCEGVALV VAQTKAISGL TIDGHAVGAK LTWEAVPGSE FSYAEVELGT ADMIHTAEAT TNLGLLTFGL AKAIGYATAA DCGRTVLSPV EPSCEGMQCA AGQRCQVVGG KAGCVAESTA VCRAQGDPHY TTFDGRRYDM MGTCSYTMVE LCSEDDTLPA FSVEAKNEHR GSRRVSYVGL VTVRAYSHSV SLTRGEVGFV LVDNQRSRLP VSLSEGRLRV YQSGPRAVVE LVFGLVVTYD WDCQLALSLP ARFQDQVCGL CGNYNGDPAD DFLTPDGALA PDAVEFASSW KLDDGDYLCE DGCQNNCPAC TPGQAQHYEG DRLCGMLTKL DGPFAVCHDT LDPRPFLEQC VYDLCVVGGE RLSLCRGLSA YAQACLELGI SVGDWRSPAN CPLSCPANSR YELCGPACPT SCNGAAAPSN CSGRPCVEGC VCLPGFVASG GACVPASSCG CTFQGLQLAP GQEVWADELC QRRCTCNGAT HQVTCRDKQS CPAGERCSVQ NGLLGCYPDR FGTCQGSGDP HYVSFDGRRF DFMGTCTYLL VGSCGQNAAL PAFRVLVENE HRGSQTVSYT RAVRVEARGV KVAVRREYPG QVLVDDVLQY LPFQAADGQV QVFRQGRDAV VRTDFGLTVT YDWNARVTAK VPSSYAEALC GLCGNFNGDP ADDLALRGGG QAANALAFGN SWQEETRPGC GATEPGDCPK LDSLVAQQLQ SKNECGILAD PKGPFRECHS KLDPQGAVRD CVYDRCLLPG QSGPLCDALA TYAAACQAAG ATVHPWRSEE LCPLSCPPHS HYEACSYGCP LSCGDLPVPG GCGSECHEGC VCDEGFALSG ESCLPLASCG CVHQGTYHPP GQTFYPGPGC DSLCHCQEGG LVSCESSSCG PHEACQPSGG SLGCVAVGSS TCQASGDPHY TTFDGRRFDF MGTCVYVLAQ TCGTRPGLHR FAVLQENVAW GNGRVSVTRV ITVQVANFTL RLEQRQWKVT VNGVDMKLPV VLANGQIRAS QHGSDVVIET DFGLRVAYDL VYYVRVTVPG NYYQQMCGLC GNYNGDPKDD FQKPNGSQAG NANEFGNSWE EVVPDSPCLP PTPCPPGSED CIPSHKCPPE LEKKYQKEEF CGLLSSPTGP LSSCHKLVDP QGPLKDCIFD LCLGGGNLSI LCSNIHAYVS ACQAAGGHVE PWRTETFCPM ECPPNSHYEL CADTCSLGCS ALSAPPQCQD GCAEGCQCDS GFLYNGQACV PIQQCGCYHN GVYYEPEQTV LIDNCRQQCT CHAGKGMVCQ EHSCKPGQVC QPSGGILSCV TKDPCHGVTC RPQETCKEQG GQGVCLPNYE ATCWLWGDPH YHSFDGRKFD FQGTCNYVLA TTGCPGVSTQ GLTPFTVTTK NQNRGNPAVS YVRVVTVAAL GTNISIHKDE IGKVRVNGVL TALPVSVADG RISVTQGASK ALLVADFGLQ VSYDWNWRVD VTLPSSYHGA VCGLCGNMDR NPNNDQVFPN GTLAPSIPIW GGSWRAPGWD PLCWDECRGS CPTCPEDRLE QYEGPGFCGP LAPGTGGPFT TCHAHVPPES FFKGCVLDVC MGGGDRDILC KALASYVAAC QAAGVVIEDW RAQVGCEITC PENSHYEVCG SPCPASCPSP APLTTPAVCE GPCVEGCQCD AGFVLSADRC VPLNNGCGCW ANGTYHEAGS EFWADGTCSQ WCRCGPGGGS LVCTPASCGL GEVCGLLPSG QHGCQPVSTA ECQAWGDPHY VTLDGHRFNF QGTCEYLLSA PCHGPPLGAE NFTVTVANEH RGSQAVSYTR SVTLQIYNHS LTLSARWPRK LQVDGVFVTL PFQLDSLLHA HLSGADVVVT TTSGLSLAFD GDSFVRLRVP AAYAGSLCGL CGNYNQDPAD DLKAVGGKPA GWQVGGAQGC GECVSKPCPS PCTPEQQESF GGPDACGVIS ATDGPLAPCH GLVPPAQYFQ GCLLDACQVQ GHPGGLCPAV ATYVAACQAA GAQLREWRRP DFCPFQCPAH SHYELCGDSC PGSCPSLSAP EGCESACREG CVCDAGFVLS GDTCVPVGQC GCLHDDRYYP LGQTFYPGPG CDSLCRCREG GEVSCEPSSC GPHETCRPSG GSLGCVAVGS TTCQASGDPH YTTFDGRRFD FMGTCVYVLA QTCGTRPGLH RFAVLQENVA WGNGRVSVTR VITVQVANFT LRLEQRQWKV TVNGVDMKLP VVLANGQIRA SQHGSDVVIE TDFGLRVAYD LVYYVRVTVP GNYYQLMCGL CGNYNGDPKD DFQKPNGSQA GNANEFGNSW EEVVPDSPCL PPPTCPPGSE GCIPSEECPP ELEKKYQKEE FCGLLSSPTG PLSSCHKLVD PQGPLKDCIF DLCLGGGNLS ILCSNIHAYV SACQAAGGQV EPWRNETFCP MECPQNSHYE LCADTCSLGC SALSAPLQCP DGCAEGCQCD SGFLYNGQAC VPIQQCGCYH NGAYYEPEQT VLIDNCRQQC TCHVGKVVVC QEHSCKPGQV CQPSGGILSC VNKDPCHGVT CRPQETCKEQ GGQGVCLPNY EATCWLWGDP HYHSFDGRKF DFQGTCNYVL ATTGCPGVST QGLTPFTVTT KNQNRGNPAV SYVRVVTVAA LGTNISIHKD EIGKVRVNGV LTALPVSVAD GRISVTQGAS KALLVADFGL QVSYDWNWRV DVTLPSSYHG AVCGLCGNMD RNPNNDQVFP NGTLAPSIPI WGGSWRAPGW DPLCWDECRG SCPTCPEDRL EQYEGPGFCG PLAPGTGGPF TTCHAHVPPE SFFKGCVLDV CMGGGDRDIL CKALASYVAA CQAAGVVIED WRAQVGCEIT CPENSHYEVC GPPCPASCPS PAPLTTPAVC EGPCVEGCQC DAGFVLSADR CVPLNNGCGC WANGTYHEAG SEFWADGTCS QWCRCGPGGG SLVCTPASCG LGEVCGLLPS GQHGCQPVST AECQAWGDPH YVTLDGHRFD FQGTCEYLLS APCHGPPLGA ENFTVTVANE HRGSQAVSYT RSVTLQIYNH SLTLSARWPR KLQVDGVFVT LPFQLDSLLH AHLSGADVVV TTTSGLSLAF DGDSFVRLRV PAAYAGSLCG LCGNYNQDPA DDLKAVGGKP AGWQVGGAQG CGECVSKPCP SPCTPEQQES FGGPDACGVI SATDGPLAPC HGLVPPAQYF QGCLLDACQV QGHPGGLCPA VATYVAACQA AGAQLREWRR PDFCPFQCPA HSHYELCGDS CPGSCPSLSA PEGCESACRE GCVCDAGFVL SGDTCVPVGQ CGCLHDDRYY PLGQTFYPGP GCDSLCRCRE GGEVSCEPSS CGPHETCRPS GGSLGCVAVG STTCQASGDP HYTTFDGHRF DFMGTCVYVL AQTCGTRPGL HRFAVLQENV AWGNGRVSVT RVITVQVANF TLRLEQRQWK VTVNGVDMKL PVVLANGQIR ASQHGSDVVI ETDFGLRVAY DLVYYVRVTV PGNYYQLMCG LCGNYNGDPK DDFQKPNGSQ AGNANEFGNS WEEVVPDSPC LPPPTCPPGS AGCIPSDKCP PELEKKYQKE EFCGLLSSPT GPLSSCHKLV DPQGPLKDCI FDLCLGGGNL SILCSNIHAY VSACQAAGGH VEPWRNETFC PMECPQNSHY ELCADTCSLG CSALSAPLQC PDGCAEGCQC DSGFLYNGQA CVPIQQCGCY HNGVYYEPEQ TVLIDNCRQQ CTCHVGKVVV CQEHSCKPGQ VCQPSGGILS CVTKDPCHGV TCRPQETCKE QGGQGVCLPN YEATCWLWGD PHYHSFDGRK FDFQGTCNYV LATTGCPGVS TQGLTPFTVT TKNQNRGNPA VSYVRVVTVA ALGTNISIHK DEIGKVRVNG VLTALPVSVA DGRISVAQGA SKALLVADFG LQVSYDWNWR VDVTLPSSYH GAVCGLCGNM DRNPNNDQVF PNGTLAPSIP IWGGSWRAPG WDPLCWDECR GSCPTCPEDR LEQYEGPGFC GPLSSGTGGP FTTCHAHVPP ESFFKGCVLD VCMGGGDRDI LCKALASYVA ACQAAGVVIE DWRAQVGCEI TCPENSHYEV CGPPCPASCP SPAPLTTPAV CEGPCVEGCQ CDAGFVLSAD RCVPLNNGCG CWANGTYHEA GSEFWADGTC SQWCRCGPGG GSLVCTPASC GLGEVCGLLP SGQHGCQPVS TAECQAWGDP HYVTLDGHRF DFQGTCEYLL SAPCHGPPLG AENFTVTVAN EHRGSQAVSY TRSVTLQIYN HSLTLSARWP RKLQVDGVFV ALPFQLDSLL HAHLSGADVV VTTTSGLSLA FDGDSFVRLR VPAAYAASLC GLCGNYNQDP ADDLKAVGGK PAGWQVGGAQ GCGECVSKPC PSPCTPEQQE SFGGPDACGV ISATDGPLAP CHGLVPPAQY FQGCLLDACQ VQGHPGGLCP AVATYVAACQ AAGAQLGEWR RPDFCPLQCP AHSHYELCGD SCPVSCPSLS APEGCESACR EGCVCDAGFV LSGDTCVPVG QCGCLHDGRY YPLGEVFYPG PECERRCECG PGGHVTCQEG AACGPHEECR LEDGVQACHA TGCGRCLANG GIHYITLDGR VYDLHGSCSY VLAQVCHPKP GDEDFSIVLE KNAAGDLQRL LVTVAGQVVS LAQGQQVTVD GEAVALPVAV GRVRVTAEGR NMVLQTTKGL RLLFDGDAHL LMSIPSPFRG RLCGLCGNFN GNWSDDFVLP NGSAASSVET FGAAWRAPGS SKGCGEGCGP QGCPVCLAEE TAPYESNEAC GQLRNPQGPF ATCQAVLSPS EYFRQCVYDL CAQKGDKAFL CRSLAAYTAA CQAAGVAVKP WRTDSFCPLH CPAHSHYSIC TRTCQGSCAA LSGLTGCTTR CFEGCECDDR FLLSQGVCIP VQDCGCTHNG RYLPVNSSLL TSDCSERCSC SSSSGLTCQA AGCPPGRVCE VKAEARNCWA TRGLCVLSVG ANLTTFDGAR GATTSPGVYE LSSRCPGLQN TIPWYRVVAE VQICHGKTEA VGQVHIFFQD GMVTLTPNKG VWVNGLRVDL PAEKLASVSV SRTPDGSLLV RQKAGVQVWL GANGKVAVIV SNDHAGKLCG ACGNFDGDQT NDWHDSQEKP AMEKWRAQDF SPCYG
Секретований назовні.
Johansson M.E.V., Thomsson K.A., Hansson G.C. (2009). Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J. Proteome Res . 8 : 3549—3557. PMID 19432394 DOI :10.1021/pr9002504
