Небулін
NEB (англ. Nebulin) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 6 669 амінокислот, а молекулярна маса — 772 914[5].
Послідовність амінокислот
10 | 20 | 30 | 40 | 50 | ||||
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MADDEDYEEV | VEYYTEEVVY | EEVPGETITK | IYETTTTRTS | DYEQSETSKP | ||||
ALAQPALAQP | ASAKPVERRK | VIRKKVDPSK | FMTPYIAHSQ | KMQDLFSPNK | ||||
YKEKFEKTKG | QPYASTTDTP | ELRRIKKVQD | QLSEVKYRMD | GDVAKTICHV | ||||
DEKAKDIEHA | KKVSQQVSKV | LYKQNWEDTK | DKYLLPPDAP | ELVQAVKNTA | ||||
MFSKKLYTED | WEADKSLFYP | YNDSPELRRV | AQAQKALSDV | AYKKGLAEQQ | ||||
AQFTPLADPP | DIEFAKKVTN | QVSKQKYKED | YENKIKGKWS | ETPCFEVANA | ||||
RMNADNISTR | KYQEDFENMK | DQIYFMQTET | PEYKMNKKAG | VAASKVKYKE | ||||
DYEKNKGKAD | YNVLPASENP | QLRQLKAAGD | ALSDKLYKEN | YEKTKAKSIN | ||||
YCETPKFKLD | TVLQNFSSDK | KYKDSYLKDI | LGHYVGSFED | PYHSHCMKVT | ||||
AQNSDKNYKA | EYEEDRGKGF | FPQTITQEYE | AIKKLDQCKD | HTYKVHPDKT | ||||
KFTQVTDSPV | LLQAQVNSKQ | LSDLNYKAKH | ESEKFKCHIP | PDTPAFIQHK | ||||
VNAYNLSDNL | YKQDWEKSKA | KKFDIKVDAI | PLLAAKANTK | NTSDVMYKKD | ||||
YEKNKGKMIG | VLSINDDPKM | LHSLKVAKNQ | SDRLYKENYE | KTKAKSMNYC | ||||
ETPKYQLDTQ | LKNFSEARYK | DLYVKDVLGH | YVGSMEDPYH | THCMKVAAQN | ||||
SDKSYKAEYE | EDKGKCYFPQ | TITQEYEAIK | KLDQCKDHTY | KVHPDKTKFT | ||||
AVTDSPVLLQ | AQLNTKQLSD | LNYKAKHEGE | KFKCHIPADA | PQFIQHRVNA | ||||
YNLSDNVYKQ | DWEKSKAKKF | DIKVDAIPLL | AAKANTKNTS | DVMYKKDYEK | ||||
SKGKMIGALS | INDDPKMLHS | LKTAKNQSDR | EYRKDYEKSK | TIYTAPLDML | ||||
QVTQAKKSQA | IASDVDYKHI | LHSYSYPPDS | INVDLAKKAY | ALQSDVEYKA | ||||
DYNSWMKGCG | WVPFGSLEME | KAKRASDILN | EKKYRQHPDT | LKFTSIEDAP | ||||
ITVQSKINQA | QRSDIAYKAK | GEEIIHKYNL | PPDLPQFIQA | KVNAYNISEN | ||||
MYKADLKDLS | KKGYDLRTDA | IPIRAAKAAR | QAASDVQYKK | DYEKAKGKMV | ||||
GFQSLQDDPK | LVHYMNVAKI | QSDREYKKDY | EKTKSKYNTP | HDMFNVVAAK | ||||
KAQDVVSNVN | YKHSLHHYTY | LPDAMDLELS | KNMMQIQSDN | VYKEDYNNWM | ||||
KGIGWIPIGS | LDVEKVKKAG | DALNEKKYRQ | HPDTLKFTSI | VDSPVMVQAK | ||||
QNTKQVSDIL | YKAKGEDVKH | KYTMSPDLPQ | FLQAKCNAYN | ISDVCYKRDW | ||||
YDLIAKGNNV | LGDAIPITAA | KASRNIASDY | KYKEAYEKSK | GKHVGFRSLQ | ||||
DDPKLVHYMN | VAKLQSDREY | KKNYENTKTS | YHTPGDMVSI | TAAKMAQDVA | ||||
TNVNYKQPLH | HYTYLPDAMS | LEHTRNVNQI | QSDNVYKDEY | NSFLKGIGWI | ||||
PIGSLEVEKV | KKAGDALNER | KYRQHPDTVK | FTSVPDSMGM | VLAQHNTKQL | ||||
SDLNYKVEGE | KLKHKYTIDP | ELPQFIQAKV | NALNMSDAHY | KADWKKTIAK | ||||
GYDLRPDAIP | IVAAKSSRNI | ASDCKYKEAY | EKAKGKQVGF | LSLQDDPKLV | ||||
HYMNVAKIQS | DREYKKGYEA | SKTKYHTPLD | MVSVTAAKKS | QEVATNANYR | ||||
QSYHHYTLLP | DALNVEHSRN | AMQIQSDNLY | KSDFTNWMKG | IGWVPIESLE | ||||
VEKAKKAGEI | LSEKKYRQHP | EKLKFTYAMD | TMEQALNKSN | KLNMDKRLYT | ||||
EKWNKDKTTI | HVMPDTPDIL | LSRVNQITMS | DKLYKAGWEE | EKKKGYDLRP | ||||
DAIAIKAARA | SRDIASDYKY | KKAYEQAKGK | HIGFRSLEDD | PKLVHFMQVA | ||||
KMQSDREYKK | GYEKSKTSFH | TPVDMLSVVA | AKKSQEVATN | ANYRNVIHTY | ||||
NMLPDAMSFE | LAKNMMQIQS | DNQYKADYAD | FMKGIGWLPL | GSLEAEKNKK | ||||
AMEIISEKKY | RQHPDTLKYS | TLMDSMNMVL | AQNNAKIMNE | HLYKQAWEAD | ||||
KTKVHIMPDI | PQIILAKANA | INMSDKLYKL | SLEESKKKGY | DLRPDAIPIK | ||||
AAKASRDIAS | DYKYKYNYEK | GKGKMVGFRS | LEDDPKLVHS | MQVAKMQSDR | ||||
EYKKNYENTK | TSYHTPADML | SVTAAKDAQA | NITNTNYKHL | IHKYILLPDA | ||||
MNIELTRNMN | RIQSDNEYKQ | DYNEWYKGLG | WSPAGSLEVE | KAKKATEYAS | ||||
DQKYRQHPSN | FQFKKLTDSM | DMVLAKQNAH | TMNKHLYTID | WNKDKTKIHV | ||||
MPDTPDILQA | KQNQTLYSQK | LYKLGWEEAL | KKGYDLPVDA | ISVQLAKASR | ||||
DIASDYKYKQ | GYRKQLGHHV | GFRSLQDDPK | LVLSMNVAKM | QSEREYKKDF | ||||
EKWKTKFSSP | VDMLGVVLAK | KCQELVSDVD | YKNYLHQWTC | LPDQNDVVQA | ||||
KKVYELQSEN | LYKSDLEWLR | GIGWSPLGSL | EAEKNKRASE | IISEKKYRQP | ||||
PDRNKFTSIP | DAMDIVLAKT | NAKNRSDRLY | REAWDKDKTQ | IHIMPDTPDI | ||||
VLAKANLINT | SDKLYRMGYE | ELKRKGYDLP | VDAIPIKAAK | ASREIASEYK | ||||
YKEGFRKQLG | HHIGARNIED | DPKMMWSMHV | AKIQSDREYK | KDFEKWKTKF | ||||
SSPVDMLGVV | LAKKCQTLVS | DVDYKNYLHQ | WTCLPDQSDV | IHARQAYDLQ | ||||
SDNLYKSDLQ | WLKGIGWMTS | GSLEDEKNKR | ATQILSDHVY | RQHPDQFKFS | ||||
SLMDSIPMVL | AKNNAITMNH | RLYTEAWDKD | KTTVHIMPDT | PEVLLAKQNK | ||||
VNYSEKLYKL | GLEEAKRKGY | DMRVDAIPIK | AAKASRDIAS | EFKYKEGYRK | ||||
QLGHHIGARA | IRDDPKMMWS | MHVAKIQSDR | EYKKDFEKWK | TKFSSPVDML | ||||
GVVLAKKCQT | LVSDVDYKNY | LHQWTCLPDQ | SDVIHARQAY | DLQSDNMYKS | ||||
DLQWMRGIGW | VSIGSLDVEK | CKRATEILSD | KIYRQPPDRF | KFTSVTDSLE | ||||
QVLAKNNAIT | MNKRLYTEAW | DKDKTQIHIM | PDTPEIMLAR | QNKINYSETL | ||||
YKLANEEAKK | KGYDLRSDAI | PIVAAKASRD | VISDYKYKDG | YRKQLGHHIG | ||||
ARNIEDDPKM | MWSMHVAKIQ | SDREYKKDFE | KWKTKFSSPV | DMLGVVLAKK | ||||
CQTLVSDVDY | KNYLHEWTCL | PDQNDVIHAR | QAYDLQSDNI | YKSDLQWLRG | ||||
IGWVPIGSMD | VVKCKRAAEI | LSDNIYRQPP | DKLKFTSVTD | SLEQVLAKNN | ||||
ALNMNKRLYT | EAWDKDKTQV | HIMPDTPEIM | LARQNKINYS | ESLYRQAMEE | ||||
AKKEGYDLRS | DAIPIVAAKA | SRDIASDYKY | KEAYRKQLGH | HIGARAVHDD | ||||
PKIMWSLHIA | KVQSDREYKK | DFEKYKTRYS | SPVDMLGIVL | AKKCQTLVSD | ||||
VDYKHPLHEW | ICLPDQNDII | HARKAYDLQS | DNLYKSDLEW | MKGIGWVPID | ||||
SLEVVRAKRA | GELLSDTIYR | QRPETLKFTS | ITDTPEQVLA | KNNALNMNKR | ||||
LYTEAWDNDK | KTIHVMPDTP | EIMLAKLNRI | NYSDKLYKLA | LEESKKEGYD | ||||
LRLDAIPIQA | AKASRDIASD | YKYKEGYRKQ | LGHHIGARNI | KDDPKMMWSI | ||||
HVAKIQSDRE | YKKEFEKWKT | KFSSPVDMLG | VVLAKKCQIL | VSDIDYKHPL | ||||
HEWTCLPDQN | DVIQARKAYD | LQSDAIYKSD | LEWLRGIGWV | PIGSVEVEKV | ||||
KRAGEILSDR | KYRQPADQLK | FTCITDTPEI | VLAKNNALTM | SKHLYTEAWD | ||||
ADKTSIHVMP | DTPDILLAKS | NSANISQKLY | TKGWDESKMK | DYDLRADAIS | ||||
IKSAKASRDI | ASDYKYKEAY | EKQKGHHIGA | QSIEDDPKIM | CAIHAGKIQS | ||||
EREYKKEFQK | WKTKFSSPVD | MLSILLAKKC | QTLVTDIDYR | NYLHEWTCMP | ||||
DQNDIIQAKK | AYDLQSDALY | KADLEWLRGI | GWMPQGSPEV | LRVKNAQNIF | ||||
CDSVYRTPVV | NLKYTSIVDT | PEVVLAKSNA | ENISIPKYRE | VWDKDKTSIH | ||||
IMPDTPEINL | ARANALNVSN | KLYREGWDEM | KAGCDVRLDA | IPIQAAKASR | ||||
EIASDYKYKL | DHEKQKGHYV | GTLTARDDNK | IRWALIADKL | QNEREYRLDW | ||||
AKWKAKIQSP | VDMLSILHSK | NSQALVSDMD | YRNYLHQWTC | MPDQNDVIQA | ||||
KKAYELQSDN | VYKADLEWLR | GIGWMPNDSV | SVNHAKHAAD | IFSEKKYRTK | ||||
IETLNFTPVD | DRVDYVTAKQ | SGEILDDIKY | RKDWNATKSK | YTLTETPLLH | ||||
TAQEAARILD | QYLYKEGWER | QKATGYILPP | DAVPFVHAHH | CNDVQSELKY | ||||
KAEHVKQKGH | YVGVPTMRDD | PKLVWFEHAG | QIQNERLYKE | DYHKTKAKIN | ||||
IPADMVSVLA | AKQGQTLVSD | IDYRNYLHQW | MCHPDQNDVI | QARKAYDLQS | ||||
DNVYRADLEW | LRGIGWIPLD | SVDHVRVTKN | QEMMSQIKYK | KNALENYPNF | ||||
RSVVDPPEIV | LAKINSVNQS | DVKYKETFNK | AKGKYTFSPD | TPHISHSKDM | ||||
GKLYSTILYK | GAWEGTKAYG | YTLDERYIPI | VGAKHADLVN | SELKYKETYE | ||||
KQKGHYLAGK | VIGEFPGVVH | CLDFQKMRSA | LNYRKHYEDT | KANVHIPNDM | ||||
MNHVLAKRCQ | YILSDLEYRH | YFHQWTSLLE | EPNVIRVRNA | QEILSDNVYK | ||||
DDLNWLKGIG | CYVWDTPQIL | HAKKSYDLQS | QLQYTAAGKE | NLQNYNLVTD | ||||
TPLYVTAVQS | GINASEVKYK | ENYHQIKDKY | TTVLETVDYD | RTRNLKNLYS | ||||
SNLYKEAWDR | VKATSYILPS | STLSLTHAKN | QKHLASHIKY | REEYEKFKAL | ||||
YTLPRSVDDD | PNTARCLRVG | KLNIDRLYRS | VYEKNKMKIH | IVPDMVEMVT | ||||
AKDSQKKVSE | IDYRLRLHEW | ICHPDLQVND | HVRKVTDQIS | DIVYKDDLNW | ||||
LKGIGCYVWD | TPEILHAKHA | YDLRDDIKYK | AHMLKTRNDY | KLVTDTPVYV | ||||
QAVKSGKQLS | DAVYHYDYVH | SVRGKVAPTT | KTVDLDRALH | AYKLQSSNLY | ||||
KTSLRTLPTG | YRLPGDTPHF | KHIKDTRYMS | SYFKYKEAYE | HTKAYGYTLG | ||||
PKDVPFVHVR | RVNNVTSERL | YRELYHKLKD | KIHTTPDTPE | IRQVKKTQEA | ||||
VSELIYKSDF | FKMQGHMISL | PYTPQVIHCR | YVGDITSDIK | YKEDLQVLKG | ||||
FGCFLYDTPD | MVRSRHLRKL | WSNYLYTDKA | RKMRDKYKVV | LDTPEYRKVQ | ||||
ELKTHLSELV | YRAAGKKQKS | IFTSVPDTPD | LLRAKRGQKL | QSQYLYVELA | ||||
TKERPHHHAG | NQTTALKHAK | DVKDMVSEKK | YKIQYEKMKD | KYTPVPDTPI | ||||
LIRAKRAYWN | ASDLRYKETF | QKTKGKYHTV | KDALDIVYHR | KVTDDISKIK | ||||
YKENYMSQLG | IWRSIPDRPE | HFHHRAVTDT | VSDVKYKEDL | TWLKGIGCYA | ||||
YDTPDFTLAE | KNKTLYSKYK | YKEVFERTKS | DFKYVADSPI | NRHFKYATQL | ||||
MNEKKYRADY | EQRKDKYHLV | VDEPRHLLAK | TAGDQISQIK | YRKNYEKSKD | ||||
KFTSIVDTPE | HLRTTKVNKQ | ISDILYKLEY | NKAKPRGYTT | IHDTPMLLHV | ||||
RKVKDEVSDL | KYKEVYQRNK | SNCTIEPDAV | HIKAAKDAYK | VNTNLDYKKQ | ||||
YEANKAHWKW | TPDRPDFLQA | AKSSLQQSDF | EYKLDREFLK | GCKLSVTDDK | ||||
NTVLALRNTL | IESDLKYKEK | HVKERGTCHA | VPDTPQILLA | KTVSNLVSEN | ||||
KYKDHVKKHL | AQGSYTTLPE | TRDTVHVKEV | TKHVSDTNYK | KKFVKEKGKS | ||||
NYSIMLEPPE | VKHAMEVAKK | QSDVAYRKDA | KENLHYTTVA | DRPDIKKATQ | ||||
AAKQASEVEY | RAKHRKEGSH | GLSMLGRPDI | EMAKKAAKLS | SQVKYRENFD | ||||
KEKGKTPKYN | PKDSQLYKVM | KDANNLASEV | KYKADLKKLH | KPVTDMKESL | ||||
IMNHVLNTSQ | LASSYQYKKK | YEKSKGHYHT | IPDNLEQLHL | KEATELQSIV | ||||
KYKEKYEKER | GKPMLDFETP | TYITAKESQQ | MQSGKEYRKD | YEESIKGRNL | ||||
TGLEVTPALL | HVKYATKIAS | EKEYRKDLEE | SIRGKGLTEM | EDTPDMLRAK | ||||
NATQILNEKE | YKRDLELEVK | GRGLNAMANE | TPDFMRARNA | TDIASQIKYK | ||||
QSAEMEKANF | TSVVDTPEII | HAQQVKNLSS | QKKYKEDAEK | SMSYYETVLD | ||||
TPEIQRVREN | QKNFSLLQYQ | CDLKNSKGKI | TVVQDTPEIL | RVKENQKNFS | ||||
SVLYKEDVSP | GTAIGKTPEM | MRVKQTQDHI | SSVKYKEAIG | QGTPIPDLPE | ||||
VKRVKETQKH | ISSVMYKENL | GTGIPTTVTP | EIERVKRNQE | NFSSVLYKEN | ||||
LGKGIPTPIT | PEMERVKRNQ | ENFSSVLYKE | NMGKGTPLAV | TPEMERVKHN | ||||
QENISSVLYK | ENVGKATATP | VTPEMQRVKR | NQENISSVLY | KENLGKATPT | ||||
PFTPEMERVK | RNQENFSSVL | YKENMRKATP | TPVTPEMERA | KRNQENISSV | ||||
LYSDSFRKQI | QGKAAYVLDT | PEMRRVRETQ | RHISTVKYHE | DFEKHKGCFT | ||||
PVVTDPITER | VKKNMQDFSD | INYRGIQRKV | VEMEQKRNDQ | DQETITGLRV | ||||
WRTNPGSVFD | YDPAEDNIQS | RSLHMINVQA | QRRSREQSRS | ASALSISGGE | ||||
EKSEHSEAPD | HHLSTYSDGG | VFAVSTAYKH | AKTTELPQQR | SSSVATQQTT | ||||
VSSIPSHPST | AGKIFRAMYD | YMAADADEVS | FKDGDAIINV | QAIDEGWMYG | ||||
TVQRTGRTGM | LPANYVEAI |
Кодований геном білок за функцією належить до м'язових білків. Задіяний у таких біологічних процесах як поліморфізм, альтернативний сплайсинг. Білок має сайт для зв'язування з молекулою актину. Локалізований у цитоплазмі, цитоскелеті.
Література
- Labeit S., Kolmerer B. (1995). The complete primary structure of human nebulin and its correlation to muscle structure. J. Mol. Biol. 248: 308—315. PMID 7739042 DOI:10.1016/S0022-2836(95)80052-2
- Ma K., Wang K. (2002). Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin. FEBS Lett. 532: 273—278. PMID 12482578 DOI:10.1016/S0014-5793(02)03655-4
- Politou A.S., Millevoi S., Gautel M., Kolmerer B., Pastore A. (1998). SH3 in muscles: solution structure of the SH3 domain from nebulin. J. Mol. Biol. 276: 189—202. PMID 9514727 DOI:10.1006/jmbi.1997.1521
- Jin J.P., Wang K. (1991). Cloning, expression, and protein interaction of human nebulin fragments composed of varying numbers of sequence modules. J. Biol. Chem. 266: 21215—21223. PMID 1682316
Примітки
- ↑ Захворювання, генетично пов'язані з NEB переглянути/редагувати посилання на ВікіДаних.
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:7720 (англ.) . Процитовано 28 серпня 2017.
- ↑ UniProt, P20929 (англ.) . Процитовано 28 серпня 2017.
Див. також
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