Матеріал з Вікіпедії — вільної енциклопедії.
DNHD1 (англ. Dynein heavy chain domain 1 ) – білок, який кодується однойменним геном, розташованим у людей на 11-й хромосомі.[3] амінокислот , а молекулярна маса — 533 644[4]
Послідовність амінокислот
10 20 30 40 50 MVPEERRVGL SSDETSSDSL KSWHSICVLD SKEQPLACQQ KQRQFVKPVT ESEQPTVLEL LLAELRTLFS AVLQDSSPAA WRYLHAVLGL LPPYRELLVG HLDLLPFLEQ LYCWAPWVQT HLHLDLLGAI VQAFPPDSSL LDSASHADCC PQKRRLHHRP PCPACPFVQA QWSRQQVKEE LATWLRPLTL PELQRCLGIV GAQVALEEAV WLDGLSLLPL ALAADIPVRY ESSDTDNAEV EPVGRKETRS QLDYEVPREK AFQKSSTGFS PETSFLDSQV MTALKMERYL KKIHFLYLNV APSRYFRPYS LMVVPPDKVN PEHYIFSPFG ILHVHPVEGS ETMTLGTWHH HCVLWQQLQF IPFFKYCLLR KSFTCWKKNV RLQGLHRLQK FLENHLLLAV PHFGAGLLHI SRLLQELHSV SWLPQELDRC YELLDLQTAL AEEKHKALRL LHRCLNLCTS ILRLVHEDTY HMQQCLQERV QNCDRIRTGQ GSIYLQRVQH KQLEQKLKQA EAWWLQLGKF ARLVDYMICQ SLISVLEEQI TSFVANILQA PRQKPFLSSQ LVFDDHGQLS HVPCVENMIQ TLTGGLQSVK TSALQVVQSA DLKTSSDSLY SEEEDEEEDS KDEFLMPKFQ GQPSDAVSIF CGPNVGLVWP WKSHPIAGIL EVRGCRLRGQ YFPHNYKQLE EDLDNNPKIQ QALNIQQVLL EGVLCKVQEF CREHHWITGI YEFLQSWGPQ KLEDMRGGPI KNYVTLVSRL NVWQARVSSM PIELLTKGGL LLLSCHDVQA EMESKLNSIR KDILAHVQNE CWNLSQQLMT ELTDFMHIFR TINSDIHAIA QCTQKLNEAN EQYVELEERM EYVRALHELI RNHFSLFSAE NEALDISVRR QFGESPIPPC PPPPQPHLLH CPLLAPQLLD MWEAFQFEKS QASEFLLSKR HAIMPKLQQL MAAALAELEG LLAKALSGPF MDPTQDQRST EHQLVSLERQ FQNTVSDLSE LHHAYAIFTE DETPVPLPIC GTRPIVQQQR IWHLYRVISE NISEWKCMAF AKFSPAMAQE KTEGWLTEAA RMSTTLELHS PVLQHCMRIL GEFRSYLPLL TKLGSLHPQS LNCQCLLRAL GLGSLQTIEL LTLGQLLTYP LLEFADRINQ VWQNENERIH AQETIRRLQR YWEARQLRLL NFILHVPYEP PASERSKRQV LRSPQWEVVD KDSGTFILSD YSNLQDSIQE SLQVLSKILA IEKSGDLNKI ALEWVAIMHG LGALLEVWLT FQQKWIFLNK VLHEMKIQFP NADLNSRFKV MDDQYRTLMR ISVADPMVLS LVVPSAERSP YFQGQQLQQL LQAGSVELEG IIMSLESVLY GVCAHFPRLF FLSDSELVAL LAARLESCEA QLWVRRCFPH VHAVSFRSCP TGEKNTDDWE SSPNTQTQVE ALAVLGAGGE EVKLQGPLPL HPDLPKWLAS LEKCLRLALV HMLQGCVAAR LARGPSLGEA LKQLPKQNKL YLQLYVQHWI DLVQAFPWQC VLVAEEVVWR AEMEEALLEW GTLAMVSMHM RKLEVLVNFM RAQRASQGGQ SLPSVRQTSL LSALLVMAVT HRDIAQLLEQ HQVSDLTDFH WVRQLKYHLG SPHIIPKSPL QSLKTIASSE PSLSPAACWI DVLGRSFLYN YEYLGPRLGP LPSLLPERPA LVLLLALEEV ACGTVLGPNG VGKRAIVNSL AQALGRQLVM LPCSPQIEAQ CLSNYLNGAL QGGAWLLLEK VHQLPPGLLS ALGQRLGELH HLYAPLYQEA SRNTSTIDPT QPQLLGSSFF EKHHVSVRLG YGCLLVLRAL SSAVPANLHL LLRPVALALP DLRQVAELTL LGAGMRDAFQ MATRLSKFFS LERELVSGPL PCRLPLLKQI LEDTIRTLNV TKEEPKCQKP RSLAAIEEAA LLRSPLFSIL NGLHLHNLRG LLCALFPSAS QVLAEPMTYK LMKPLVVEEL QQVGLDPSPD ILGSLEQLSQ ALSRASGILL LGPAGSGKTT CWHSLFKIQN RLAAMEDTST QGCQPVEITH LYPSGLSPQE FLGWLEGSCW HHGIFPKVLR AAGQCNNMGQ KRQTEESIGI QHWIICDGAS NGAWLDSITC LLSELPQLSL PSGQQIARPP GTFLLMEVAD TTGISPTVVG CCALVWCGGE QTWQCILSAL MASLPYEYRL QHRTVAELNH MAEVLVPATL RFLTCQGVSS LLQVHGQQAV CAGVAEVTSM ARILHSLLDL HLRLKEEKAP GPEDLSYSDP VAQSFRSSKS SFLNRSQVDS DDVPDKCREH LLAVSSFLFA LIWGFGAHLP SRFWPIFDTF IRDSISRLSN YPEPPPSALV FDLHVSPEDG TLVPFTGQYL SSHIKGTLGT FHPSIQTERL LYVVDLLLSG GQPVLLAGEA ATGKSAFVEV LVEPHHPYIY SPIHPAFSSS HLRLLLSRGI QGQTQASPQP GHHQDSKPSL LFLLEDLHLA TSDPEKSCQP VLETLRQAMD GTVYAHSTLE LQTLQPTVNF LATVTVPGYC ERPLCPRLFR LFTVLALESM TQATLLERHV PIIQAWLERF PSVERERALA RGLVRASVEA WEAVCNCFMP SPLHPHYHFS LHSVSHLLSS LQLLPNRTGS RGFVDYPNHQ EHLRRVSGLR GTCLTVMMAT RNVVRLWLHE AQRTFCDRLD SPRERSYCAK LLLVVAQSVF CCGPGPQHLG KDHQESEEEE EEERVPEVES EGELAQWEDF SNSNSETEEE EEPYGLQVAR VSNSRDPSLT PSIGPVSRGM KESISHKIRQ EKGTRASNYR LQVRRSFKTW WQKKPQMDLI SPLLLPVLLL HPQEKPSDLV FSQELILGPN SETPNLYLER QWEKLEEQLA TSAAQLKLSP HLARCHSMAQ HVARLVRVLA RPRQHGLLLS GALGTGRHTA ITLASSICQA HFFHLPSGSE EAILQCLRDA SWHAGMLSQP VALLVPSGVD LTTLHRLLAL ATSGSFPGQY TEADLDRIGE HLPRENLGVK QNIKKEMVLQ RFHQQVCSHL HLFFLIGDKQ AHKQLPSTLF LRLLQLATAS IDRYEPWDQA ALAKVAQHHL EGAQSVPLDD GSWKYPDLQA SIPSVAKAMA LIHLSATHYH EHLCPALPLV TPKTFLDFLD TFLMLQQQTI LKIKNKAQRV QNALENLRML IKEHGTHANL IFDLEQQLKD SGKSLSMFQQ QLEQSKLLYK QQLEECRHQE NLIENLARQR DALQAQREAF LEQMSKAFLE PLSQLQVADF EEIRSYRAPP ESVVRVTDAM CDLFHHETGW ASAKQLLCTE DFYQELVFFP KEKITDSELI KLHLILKAPG MDDAALRAVS RPAASLAAWL WAVLHYGLAH CRGLPTDLLL QQVEATLTRE QARLGYYQFQ AQETLEHNLA LAKMVEDAQA SHNCVAKTLS QAQCGQYHKW PMKAALLTPM RAWTTQLQKL KGRCMTVFGD TLLCSAAIIY LGPFPPLRRQ ELLDEWLALC RGFQEALGPD DVAQALKRKQ KSVSIPPKNP LLATHSPFSI LSLLSSESEQ YQWDGNLKPQ AKSAHLAGLL LRSPTHYSSC RWPLLLDPSN EALIWLDPLP LEENRSFAPA LTEGRGKGLM RNQKRESKTD MKEEDDESEE SNEAEDQTKE QKAEERKNEQ EKEQEENEEK EEEKTESQGS KPAYETQLPS LPYLSVLSGA DPELGSQLQE AAACGLPVLL TNVELGLGCE ELQWLLQREQ LSPPQVQPGF CLYLSTTLSL CAMEKVLGCE LLKGLNVLDL GLNMEILEEQ MLHEILCREY PELETRWQDL KIRALDTCKA VEAAEERLLT MLLFQNPKRQ KPAKFLRNIV RAQGKLCQLR AHCEELEGQK LQEMVLWAPY RPVVWHGMAM VKALSQLQNL LPLFCMSPEN WLAVTKQALD SMKPREINHG EDLASHLLQL RAHLTRQLLG STVTALGLTQ VPLVGALGAL ALLQATGKAS ELERLALWPG LAASPSTVHS KPVSDVARPA WLGPKAWHEC EMLELLPPFV GLCASLAGHS SAWQAYLSLS STVLGPAPGP GPEPLSLLQK LILWRVLRPE CLAGALADFT TSLLGRPLDE NTYAPTMPFK HSQATQPMLI LLPPPGHPSA TLHPLTVIQK LAAKYQQGQK QLQVIALGSE AWDPVSVVVS TLSQAMYEGH WLVLDNCHLM PHWPKELLQL LLELLGRAKV VADLESEQLL DQPESRNVST VHRDFRLWLI VPAESSASLP AVLTQHSMPV FWNQSLELGH VLIDSVELAQ QVLYMQPPTQ ALPLLLLHGL LLHRQLYGTR LQAHRGRWSQ VTLTQVLQTQ DQLWASLSNP RAAMQELAAS VFYGGPLGDT EDREALISLT QACLSPSSGS WVQPHTPQSL LATLMPLPEL RELDAMAECK AQMHLLPSPP EPRLCGLSEG PQAWLLRRQS RALLSALQRS SPVWVPESRR GAQLAERRLR QRLVQVNRRL ESLQDLLTHV IRQDESDAPW SVLGPNARRP LEGVLETEAL ELSQLVGTLQ RDLDCLLQQL KGAPPCPSRR CAAVAHALWT GRLPLPWRPH APAGPQPPWH WLRQLSRRGQ LLVRYLGVGA DASSDVPERV FHLSAFRHPR RLLLALRGEA ALDQNVPSSN FPGSRGSVSS QLQYKRLEMN SNPLHFRVEN GPNPTVPERG LLLIGLQVLH AEWDPIAGAL QDSPSSQPSP LPPVSISTQA PGTSDLPAPA DLTVYSCPVY MGGPLGTAKL QSRNIVMHLP LPTKLTPNTC VQRRVHVCSP PLS
Задіяний у такому біологічному процесі, як альтернативний сплайсинг .
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res . 14 : 2121—2127. 2004. PMID 15489334 DOI :10.1101/gr.2596504
