ST5 (англ.Suppression of tumorigenicity 5) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 1 137 амінокислот, а молекулярна маса — 126 485[4].
Lichy J.H., Majidi M., Elbaum J., Tsai M.M. (1996). Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression. Nucleic Acids Res. 24: 4700—4708. PMID8972856DOI:10.1093/nar/24.23.4700
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID15489334DOI:10.1101/gr.2596504
Majidi M., Hubbs A.E., Lichy J.H. (1998). Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5. J. Biol. Chem. 273: 16608—16614. PMID9632734DOI:10.1074/jbc.273.26.16608
Hubbs A.E., Majidi M., Lichy J.H. (1999). Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology. Oncogene. 18: 2519—2525. PMID10229203DOI:10.1038/sj.onc.1202554
Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A. (2010). Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. J. Cell Biol. 191: 367—381. PMID20937701DOI:10.1083/jcb.201008051
Lichy J.H., Modi W.S., Seuanez H.N., Howley P.M. (1992). Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. Cell Growth Differ. 3: 541—548. PMID1390339