WNT5A

WNT5A
Ідентифікатори
Символи	WNT5A, hWnt family member 5A
Зовнішні ІД	OMIM: 164975 MGI: 98958 HomoloGene: 20720 GeneCards: WNT5A
Пов'язані генетичні захворювання
	autosomal dominant Robinow syndrome 1
Онтологія гена
Молекулярна функція	• protein domain specific binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • chemoattractant activity involved in axon guidance; • receptor tyrosine kinase-like orphan receptor binding; • signaling receptor binding; • cytokine activity; • GO:0005110 frizzled binding; • receptor ligand activity; • GO:0001948, GO:0016582 protein binding; • phospholipid binding;
Клітинна компонента	• endocytic vesicle membrane; • endoplasmic reticulum lumen; • extracellular region; • cell surface; • екзосома; • клітинна мембрана; • Golgi lumen; • clathrin-coated endocytic vesicle membrane; • міжклітинний простір; • clathrin-coated vesicle membrane; • GO:0005578 Позаклітинна матриця; • collagen-containing extracellular matrix; • postsynapse; • glutamatergic synapse;
Біологічний процес	• somitogenesis; • cellular response to retinoic acid; • planar cell polarity pathway involved in outflow tract morphogenesis; • excitatory synapse assembly; • non-canonical Wnt signaling pathway; • positive regulation of protein phosphorylation; • negative chemotaxis; • GO:1903364 positive regulation of protein catabolic process; • paraxial mesoderm formation; • convergent extension involved in axis elongation; • positive regulation of protein kinase C activity; • cellular response to molecule of bacterial origin; • positive regulation of protein localization to synapse; • hindgut morphogenesis; • positive regulation of JNK cascade; • mesodermal to mesenchymal transition involved in gastrulation; • regulation of protein localization; • heart looping; • protein phosphorylation; • epithelial cell proliferation involved in mammary gland duct elongation; • face development; • establishment of epithelial cell apical/basal polarity; • notochord morphogenesis; • positive regulation of mesenchymal cell proliferation; • mesenchymal-epithelial cell signaling; • negative regulation of epithelial cell proliferation; • planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; • cellular response to interferon-gamma; • positive regulation of thymocyte apoptotic process; • tube closure; • positive regulation of non-canonical Wnt signaling pathway; • type B pancreatic cell development; • negative regulation of mesenchymal cell proliferation; • primitive streak formation; • cellular response to transforming growth factor beta stimulus; • cellular response to calcium ion; • dopaminergic neuron differentiation; • positive regulation of type I interferon-mediated signaling pathway; • cell fate commitment; • negative regulation of fat cell differentiation; • limb morphogenesis; • convergent extension; • lung development; • positive regulation of fibroblast proliferation; • optic cup formation involved in camera-type eye development; • hematopoietic stem cell proliferation; • embryonic digit morphogenesis; • regulation of branching involved in mammary gland duct morphogenesis; • negative regulation of axon extension involved in axon guidance; • positive regulation of peptidyl-serine phosphorylation; • chemorepulsion of dopaminergic neuron axon; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of prostatic bud formation; • planar cell polarity pathway involved in cardiac right atrium morphogenesis; • positive regulation of endocytosis; • morphogenesis of an epithelium; • JNK cascade; • cartilage development; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • axis elongation; • embryonic limb morphogenesis; • positive regulation of cartilage development; • neural tube development; • pericardium morphogenesis; • positive regulation of interleukin-6 production; • post-anal tail morphogenesis; • convergent extension involved in organogenesis; • digestive tract morphogenesis; • roof of mouth development; • диференціація клітин; • neuron projection morphogenesis; • male gonad development; • positive regulation of inflammatory response; • lateral sprouting involved in mammary gland duct morphogenesis; • positive regulation of macrophage cytokine production; • positive regulation of epithelial cell proliferation; • urinary bladder development; • planar cell polarity pathway involved in ventricular septum morphogenesis; • positive regulation of JUN kinase activity; • establishment of planar polarity; • hypophysis morphogenesis; • negative regulation of synapse assembly; • Загоєння ран; • positive regulation of macrophage activation; • negative regulation of apoptotic process; • positive regulation of ossification; • planar cell polarity pathway involved in axis elongation; • negative regulation of melanin biosynthetic process; • positive regulation of angiogenesis; • embryonic skeletal system development; • cervix development; • uterus development; • Wnt signaling pathway, planar cell polarity pathway; • Wnt signaling pathway, calcium modulating pathway; • positive regulation of NF-kappaB transcription factor activity; • Епітеліально-мезенхімальний перехід; • canonical Wnt signaling pathway; • planar cell polarity pathway involved in pericardium morphogenesis; • positive regulation of protein binding; • GO:0045996 negative regulation of transcription, DNA-templated; • ameboidal-type cell migration; • midbrain development; • planar cell polarity pathway involved in gastrula mediolateral intercalation; • positive regulation of protein kinase activity; • positive regulation of cell-cell adhesion mediated by cadherin; • Нейрогенез; • activation of protein kinase B activity; • positive regulation of endothelial cell proliferation; • аксоноґенеза; • non-canonical Wnt signaling pathway via JNK cascade; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • GO:0032737 positive regulation of cytokine production; • vagina development; • positive regulation of protein kinase C signaling; • development of primary male sexual characteristics; • mammary gland branching involved in thelarche; • positive regulation of interferon-gamma production; • somite development; • keratinocyte differentiation; • planar cell polarity pathway involved in neural tube closure; • axon guidance; • negative regulation of BMP signaling pathway; • positive regulation of endothelial cell migration; • genitalia development; • negative regulation of fibroblast growth factor receptor signaling pathway; • positive regulation of response to cytokine stimulus; • multicellular organism development; • inhibitory synapse assembly; • neural tube closure; • determination of left/right symmetry; • lens development in camera-type eye; • positive regulation of peptidyl-threonine phosphorylation; • cochlea morphogenesis; • inner ear morphogenesis; • positive regulation of T cell chemotaxis; • olfactory bulb interneuron development; • positive regulation of cell population proliferation; • positive regulation of neuron projection development; • positive regulation of meiotic nuclear division; • melanocyte proliferation; • cellular response to lipopolysaccharide; • cell migration; • anterior/posterior axis specification, embryo; • chemoattraction of serotonergic neuron axon; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • anterior/posterior pattern specification; • midgut development; • planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation; • midbrain dopaminergic neuron differentiation; • neuron differentiation; • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; • negative regulation of cell proliferation in midbrain; • negative regulation of canonical Wnt signaling pathway; • planar cell polarity pathway involved in axon guidance; • Wnt signaling pathway; • response to organic substance; • positive regulation of timing of anagen; • membrane organization; • positive regulation of canonical Wnt signaling pathway; • presynapse assembly; • postsynapse assembly; • regulation of signaling receptor activity; • GO:1901313 positive regulation of gene expression; • regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of G protein-coupled receptor signaling pathway; • regulation of inflammatory response; • GO:1904739 regulation of synapse organization; • secondary palate development; • regulation of postsynapse organization; • regulation of postsynaptic cytosolic calcium ion concentration; • positive regulation of neuron projection arborization; • positive regulation of neuron death;
	Джерела:Amigo / QuickGO
Ортологи
	7474
	22418
	ENSG00000114251
	ENSMUSG00000021994
	P41221
	P22725
	NM_001256105; NM_003392; NM_001377271; NM_001377272
	NM_001256224; NM_009524
	NP_001243034; NP_003383; NP_001364200; NP_001364201
	NP_001243153; NP_033550
	Вікідані
Див./Ред. для людей	Див./Ред. для мишей

WNT5A (англ. Wnt family member 5A) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. ^[4] Довжина поліпептидного ланцюга білка становить 380 амінокислот, а молекулярна маса — 42 339^[5].

Послідовність амінокислот

10	20	30	40	50
MKKSIGILSP	GVALGMAGSA	MSSKFFLVAL	AIFFSFAQVV	IEANSWWSLG
MNNPVQMSEV	YIIGAQPLCS	QLAGLSQGQK	KLCHLYQDHM	QYIGEGAKTG
IKECQYQFRH	RRWNCSTVDN	TSVFGRVMQI	GSRETAFTYA	VSAAGVVNAM
SRACREGELS	TCGCSRAARP	KDLPRDWLWG	GCGDNIDYGY	RFAKEFVDAR
ERERIHAKGS	YESARILMNL	HNNEAGRRTV	YNLADVACKC	HGVSGSCSLK
TCWLQLADFR	KVGDALKEKY	DSAAAMRLNS	RGKLVQVNSR	FNSPTTQDLV
YIDPSPDYCV	RNESTGSLGT	QGRLCNKTSE	GMDGCELMCC	GRGYDQFKTV
QTERCHCKFH	WCCYVKCKKC	TEIVDQFVCK

A: Аланін

C: Цистеїн

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

H: Гістидин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

W: Триптофан

Y: Тирозин

Кодований геном білок за функцією належить до білків розвитку. Задіяний у таких біологічних процесах як диференціація, сигнальний шлях Wnt, альтернативний сплайсинг. Локалізований у позаклітинному матриксі. Також секретований назовні.

Література[ред. | ред. код]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504

Примітки[ред. | ред. код]

↑ Захворювання, генетично пов'язані з WNT5A переглянути/редагувати посилання на ВікіДаних.
↑ Human PubMed Reference:.
↑ Mouse PubMed Reference:.
↑ HUGO Gene Nomenclature Commitee, HGNC:12784 (англ.) . Процитовано 30 серпня 2017.
↑ UniProt, P41221 (англ.) . Архів оригіналу за 8 серпня 2017. Процитовано 30 серпня 2017.

Див. також[ред. | ред. код]

Хромосома 3

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Портал «Біологія» Портал «Хімія»

[1] Захворювання, генетично пов'язані з WNT5A переглянути/редагувати посилання на ВікіДаних.

[2] Human PubMed Reference:.

[3] Mouse PubMed Reference:.

[HGNC-4] HUGO Gene Nomenclature Commitee, HGNC:12784 (англ.) . Процитовано 30 серпня 2017.

[UniProt-5] UniProt, P41221 (англ.) . Архів оригіналу за 8 серпня 2017. Процитовано 30 серпня 2017.

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WNT5A

Література[ред. | ред. код]

Примітки[ред. | ред. код]

Див. також[ред. | ред. код]

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