ADGRV1
ADGRV1 (англ. Adhesion G protein-coupled receptor V1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 5-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 6 306 амінокислот, а молекулярна маса — 693 069[5].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSVFLGPGMP | SASLLVNLLS | ALLILFVFGE | TEIRFTGQTE | FVVNETSTTV | ||||
| IRLIIERIGE | PANVTAIVSL | YGEDAGDFFD | TYAAAFIPAG | ETNRTVYIAV | ||||
| CDDDLPEPDE | TFIFHLTLQK | PSANVKLGWP | RTVTVTILSN | DNAFGIISFN | ||||
| MLPSIAVSEP | KGRNESMPLT | LIREKGTYGM | VMVTFEVEGG | PNPPDEDLSP | ||||
| VKGNITFPPG | RATVIYNLTV | LDDEVPENDE | IFLIQLKSVE | GGAEINTSRN | ||||
| SIEIIIKKND | SPVRFLQSIY | LVPEEDHILI | IPVVRGKDNN | GNLIGSDEYE | ||||
| VSISYAVTTG | NSTAHAQQNL | DFIDLQPNTT | VVFPPFIHES | HLKFQIVDDT | ||||
| IPEIAESFHI | MLLKDTLQGD | AVLISPSVVQ | VTIKPNDKPY | GVLSFNSVLF | ||||
| ERTVIIDEDR | ISRYEEITVV | RNGGTHGNVS | ANWVLTRNST | DPSPVTADIR | ||||
| PSSGVLHFAQ | GQMLATIPLT | VVDDDLPEEA | EAYLLQILPH | TIRGGAEVSE | ||||
| PAELLFYIQD | SDDVYGLITF | FPMENQKIES | SPGERYLSLS | FTRLGGTKGD | ||||
| VRLLYSVLYI | PAGAVDPLQA | KEGILNISRR | NDLIFPEQKT | QVTTKLPIRN | ||||
| DAFLQNGAHF | LVQLETVELL | NIIPLIPPIS | PRFGEICNIS | LLVTPAIANG | ||||
| EIGFLSNLPI | ILHEPEDFAA | EVVYIPLHRD | GTDGQATVYW | SLKPSGFNSK | ||||
| AVTPDDIGPF | NGSVLFLSGQ | SDTTINITIK | GDDIPEMNET | VTLSLDRVNV | ||||
| ENQVLKSGYT | SRDLIILEND | DPGGVFEFSP | ASRGPYVIKE | GESVELHIIR | ||||
| SRGSLVKQFL | HYRVEPRDSN | EFYGNTGVLE | FKPGEREIVI | TLLARLDGIP | ||||
| ELDEHYWVVL | SSHGERESKL | GSATIVNITI | LKNDDPHGII | EFVSDGLIVM | ||||
| INESKGDAIY | SAVYDVVRNR | GNFGDVSVSW | VVSPDFTQDV | FPVQGTVVFG | ||||
| DQEFSKNITI | YSLPDEIPEE | MEEFTVILLN | GTGGAKVGNR | TTATLRIRRN | ||||
| DDPIYFAEPR | VVRVQEGETA | NFTVLRNGSV | DVTCMVQYAT | KDGKATARER | ||||
| DFIPVEKGET | LIFEVGSRQQ | SISIFVNEDG | IPETDEPFYI | ILLNSTGDTV | ||||
| VYQYGVATVI | IEANDDPNGI | FSLEPIDKAV | EEGKTNAFWI | LRHRGYFGSV | ||||
| SVSWQLFQND | SALQPGQEFY | ETSGTVNFMD | GEEAKPIILH | AFPDKIPEFN | ||||
| EFYFLKLVNI | SGGSPGPGGQ | LAETNLQVTV | MVPFNDDPFG | VFILDPECLE | ||||
| REVAEDVLSE | DDMSYITNFT | ILRQQGVFGD | VQLGWEILSS | EFPAGLPPMI | ||||
| DFLLVGIFPT | TVHLQQHMRR | HHSGTDALYF | TGLEGAFGTV | NPKYHPSRNN | ||||
| TIANFTFSAW | VMPNANTNGF | IIAKDDGNGS | IYYGVKIQTN | ESHVTLSLHY | ||||
| KTLGSNATYI | AKTTVMKYLE | ESVWLHLLII | LEDGIIEFYL | DGNAMPRGIK | ||||
| SLKGEAITDG | PGILRIGAGI | NGNDRFTGLM | QDVRSYERKL | TLEEIYELHA | ||||
| MPAKSDLHPI | SGYLEFRQGE | TNKSFIISAR | DDNDEEGEEL | FILKLVSVYG | ||||
| GARISEENTT | ARLTIQKSDN | ANGLFGFTGA | CIPEIAEEGS | TISCVVERTR | ||||
| GALDYVHVFY | TISQIETDGI | NYLVDDFANA | SGTITFLPWQ | RSEVLNIYVL | ||||
| DDDIPELNEY | FRVTLVSAIP | GDGKLGSTPT | SGASIDPEKE | TTDITIKASD | ||||
| HPYGLLQFST | GLPPQPKDAM | TLPASSVPHI | TVEEEDGEIR | LLVIRAQGLL | ||||
| GRVTAEFRTV | SLTAFSPEDY | QNVAGTLEFQ | PGERYKYIFI | NITDNSIPEL | ||||
| EKSFKVELLN | LEGGVAELFR | VDGSGSGDGD | MEFFLPTIHK | RASLGVASQI | ||||
| LVTIAASDHA | HGVFEFSPES | LFVSGTEPED | GYSTVTLNVI | RHHGTLSPVT | ||||
| LHWNIDSDPD | GDLAFTSGNI | TFEIGQTSAN | ITVEILPDED | PELDKAFSVS | ||||
| VLSVSSGSLG | AHINATLTVL | ASDDPYGIFI | FSEKNRPVKV | EEATQNITLS | ||||
| IIRLKGLMGK | VLVSYATLDD | MEKPPYFPPN | LARATQGRDY | IPASGFALFG | ||||
| ANQSEATIAI | SILDDDEPER | SESVFIELLN | STLVAKVQSR | SIPNSPRLGP | ||||
| KVETIAQLII | IANDDAFGTL | QLSAPIVRVA | ENHVGPIINV | TRTGGAFADV | ||||
| SVKFKAVPIT | AIAGEDYSIA | SSDVVLLEGE | TSKAVPIYVI | NDIYPELEES | ||||
| FLVQLMNETT | GGARLGALTE | AVIIIEASDD | PYGLFGFQIT | KLIVEEPEFN | ||||
| SVKVNLPIIR | NSGTLGNVTV | QWVATINGQL | ATGDLRVVSG | NVTFAPGETI | ||||
| QTLLLEVLAD | DVPEIEEVIQ | VQLTDASGGG | TIGLDRIANI | IIPANDDPYG | ||||
| TVAFAQMVYR | VQEPLERSSC | ANITVRRSGG | HFGRLLLFYS | TSDIDVVALA | ||||
| MEEGQDLLSY | YESPIQGVPD | PLWRTWMNVS | AVGEPLYTCA | TLCLKEQACS | ||||
| AFSFFSASEG | PQCFWMTSWI | SPAVNNSDFW | TYRKNMTRVA | SLFSGQAVAG | ||||
| SDYEPVTRQW | AIMQEGDEFA | NLTVSILPDD | FPEMDESFLI | SLLEVHLMNI | ||||
| SASLKNQPTI | GQPNISTVVI | ALNGDAFGVF | VIYNISPNTS | EDGLFVEVQE | ||||
| QPQTLVELMI | HRTGGSLGQV | AVEWRVVGGT | ATEGLDFIGA | GEILTFAEGE | ||||
| TKKTVILTIL | DDSEPEDDES | IIVSLVYTEG | GSRILPSSDT | VRVNILANDN | ||||
| VAGIVSFQTA | SRSVIGHEGE | ILQFHVIRTF | PGRGNVTVNW | KIIGQNLELN | ||||
| FANFSGQLFF | PEGSLNTTLF | VHLLDDNIPE | EKEVYQVILY | DVRTQGVPPA | ||||
| GIALLDAQGY | AAVLTVEASD | EPHGVLNFAL | SSRFVLLQEA | NITIQLFINR | ||||
| EFGSLGAINV | TYTTVPGMLS | LKNQTVGNLA | EPEVDFVPII | GFLILEEGET | ||||
| AAAINITILE | DDVPELEEYF | LVNLTYVGLT | MAASTSFPPR | LDSEGLTAQV | ||||
| IIDANDGARG | VIEWQQSRFE | VNETHGSLTL | VAQRSREPLG | HVSLFVYAQN | ||||
| LEAQVGLDYI | FTPMILHFAD | GERYKNVNIM | ILDDDIPEGD | EKFQLILTNP | ||||
| SPGLELGKNT | IALIIVLAND | DGPGVLSFNN | SEHFFLREPT | ALYVQESVAV | ||||
| LYIVREPAQG | LFGTVTVQFI | VTEVNSSNES | KDLTPSKGYI | VLEEGVRFKA | ||||
| LQISAILDTE | PEMDEYFVCT | LFNPTGGARL | GVHVQTLITV | LQNQAPLGLF | ||||
| SISAVENRAT | SIDIEEANRT | VYLNVSRTNG | IDLAVSVQWE | TVSETAFGMR | ||||
| GMDVVFSVFQ | SFLDESASGW | CFFTLENLIY | GIMLRKSSVT | VYRWQGIFIP | ||||
| VEDLNIENPK | TCEAFNIGFS | PYFVITHEER | NEEKPSLNSV | FTFTSGFKLF | ||||
| LVQTIIILES | SQVRYFTSDS | QDYLIIASQR | DDSELTQVFR | WNGGSFVLHQ | ||||
| KLPVRGVLTV | ALFNKGGSVF | LAISQANARL | NSLLFRWSGS | GFINFQEVPV | ||||
| SGTTEVEALS | SANDIYLIFA | ENVFLGDQNS | IDIFIWEMGQ | SSFRYFQSVD | ||||
| FAAVNRIHSF | TPASGIAHIL | LIGQDMSALY | CWNSERNQFS | FVLEVPSAYD | ||||
| VASVTVKSLN | SSKNLIALVG | AHSHIYELAY | ISSHSDFIPS | SGELIFEPGE | ||||
| REATIAVNIL | DDTVPEKEES | FKVQLKNPKG | GAEIGINDSV | TITILSNDDA | ||||
| YGIVAFAQNS | LYKQVEEMEQ | DSLVTLNVER | LKGTYGRITI | AWEADGSISD | ||||
| IFPTSGVILF | TEGQVLSTIT | LTILADNIPE | LSEVVIVTLT | RITTEGVEDS | ||||
| YKGATIDQDR | SKSVITTLPN | DSPFGLVGWR | AASVFIRVAE | PKENTTTLQL | ||||
| QIARDKGLLG | DIAIHLRAQP | NFLLHVDNQA | TENEDYVLQE | TIIIMKENIK | ||||
| EAHAEVSILP | DDLPELEEGF | IVTITEVNLV | NSDFSTGQPS | VRRPGMEIAE | ||||
| IMIEENDDPR | GIFMFHVTRG | AGEVITAYEV | PPPLNVLQVP | VVRLAGSFGA | ||||
| VNVYWKASPD | SAGLEDFKPS | HGILEFADKQ | VTAMIEITII | DDAEFELTET | ||||
| FNISLISVAG | GGRLGDDVVV | TVVIPQNDSP | FGVFGFEEKT | VMIDESLSSD | ||||
| DPDSYVTLTV | VRSPGGKGTV | RLEWTIDEKA | KHNLSPLNGT | LHFDETESQK | ||||
| TIVLHTLQDT | VLEEDRRFTI | QLISIDEVEI | SPVKGSASII | IRGDKRASGE | ||||
| VGIAPSSRHI | LIGEPSAKYN | GTAIISLVRG | PGILGEVTVF | WRIFPPSVGE | ||||
| FAETSGKLTM | RDEQSAVIVV | IQALNDDIPE | EKSFYEFQLT | AVSEGGVLSE | ||||
| SSSTANITVV | ASDSPYGRFA | FSHEQLRVSE | AQRVNITIIR | SSGDFGHVRL | ||||
| WYKTMSGTAE | AGLDFVPAAG | ELLFEAGEMR | KSLHVEILDD | DYPEGPEEFS | ||||
| LTITKVELQG | RGYDFTIQEN | GLQIDQPPEI | GNISIVRIII | MKNDNAEGII | ||||
| EFDPKYTAFE | VEEDVGLIMI | PVVRLHGTYG | YVTADFISQS | SSASPGGVDY | ||||
| ILHGSTVTFQ | HGQNLSFINI | SIIDDNESEF | EEPIEILLTG | ATGGAVLGRH | ||||
| LVSRIIIAKS | DSPFGVIRFL | NQSKISIANP | NSTMILSLVL | ERTGGLLGEI | ||||
| QVNWETVGPN | SQEALLPQNR | DIADPVSGLF | YFGEGEGGVR | TIILTIYPHE | ||||
| EIEVEETFII | KLHLVKGEAK | LDSRAKDVTL | TIQEFGDPNG | VVQFAPETLS | ||||
| KKTYSEPLAL | EGPLLITFFV | RRVKGTFGEI | MVYWELSSEF | DITEDFLSTS | ||||
| GFFTIADGES | EASFDVHLLP | DEVPEIEEDY | VIQLVSVEGG | AELDLEKSIT | ||||
| WFSVYANDDP | HGVFALYSDR | QSILIGQNLI | RSIQINITRL | AGTFGDVAVG | ||||
| LRISSDHKEQ | PIVTENAERQ | LVVKDGATYK | VDVVPIKNQV | FLSLGSNFTL | ||||
| QLVTVMLVGG | RFYGMPTILQ | EAKSAVLPVS | EKAANSQVGF | ESTAFQLMNI | ||||
| TAGTSHVMIS | RRGTYGALSV | AWTTGYAPGL | EIPEFIVVGN | MTPTLGSLSF | ||||
| SHGEQRKGVF | LWTFPSPGWP | EAFVLHLSGV | QSSAPGGAQL | RSGFIVAEIE | ||||
| PMGVFQFSTS | SRNIIVSEDT | QMIRLHVQRL | FGFHSDLIKV | SYQTTAGSAK | ||||
| PLEDFEPVQN | GELFFQKFQT | EVDFEITIIN | DQLSEIEEFF | YINLTSVEIR | ||||
| GLQKFDVNWS | PRLNLDFSVA | VITILDNDDL | AGMDISFPET | TVAVAVDTTL | ||||
| IPVETESTTY | LSTSKTTTIL | QPTNVVAIVT | EATGVSAIPE | KLVTLHGTPA | ||||
| VSEKPDVATV | TANVSIHGTF | SLGPSIVYIE | EEMKNGTFNT | AEVLIRRTGG | ||||
| FTGNVSITVK | TFGERCAQME | PNALPFRGIY | GISNLTWAVE | EEDFEEQTLT | ||||
| LIFLDGERER | KVSVQILDDD | EPEGQEFFYV | FLTNPQGGAQ | IVEEKDDTGF | ||||
| AAFAMVIITG | SDLHNGIIGF | SEESQSGLEL | REGAVMRRLH | LIVTRQPNRA | ||||
| FEDVKVFWRV | TLNKTVVVLQ | KDGVNLVEEL | QSVSGTTTCT | MGQTKCFISI | ||||
| ELKPEKVPQV | EVYFFVELYE | ATAGAAINNS | ARFAQIKILE | SDESQSLVYF | ||||
| SVGSRLAVAH | KKATLISLQV | ARDSGTGLMM | SVNFSTQELR | SAETIGRTII | ||||
| SPAISGKDFV | ITEGTLVFEP | GQRSTVLDVI | LTPETGSLNS | FPKRFQIVLF | ||||
| DPKGGARIDK | VYGTANITLV | SDADSQAIWG | LADQLHQPVN | DDILNRVLHT | ||||
| ISMKVATENT | DEQLSAMMHL | IEKITTEGKI | QAFSVASRTL | FYEILCSLIN | ||||
| PKRKDTRGFS | HFAEVTENFA | FSLLTNVTCG | SPGEKSKTIL | DSCPYLSILA | ||||
| LHWYPQQING | HKFEGKEGDY | IRIPERLLDV | QDAEIMAGKS | TCKLVQFTEY | ||||
| SSQQWFISGN | NLPTLKNKVL | SLSVKGQSSQ | LLTNDNEVLY | RIYAAEPRII | ||||
| PQTSLCLLWN | QAAASWLSDS | QFCKVVEETA | DYVECACSHM | SVYAVYARTD | ||||
| NLSSYNEAFF | TSGFICISGL | CLAVLSHIFC | ARYSMFAAKL | LTHMMAASLG | ||||
| TQILFLASAY | ASPQLAEESC | SAMAAVTHYL | YLCQFSWMLI | QSVNFWYVLV | ||||
| MNDEHTERRY | LLFFLLSWGL | PAFVVILLIV | ILKGIYHQSM | SQIYGLIHGD | ||||
| LCFIPNVYAA | LFTAALVPLT | CLVVVFVVFI | HAYQVKPQWK | AYDDVFRGRT | ||||
| NAAEIPLILY | LFALISVTWL | WGGLHMAYRH | FWMLVLFVIF | NSLQGLYVFM | ||||
| VYFILHNQMC | CPMKASYTVE | MNGHPGPSTA | FFTPGSGMPP | AGGEISKSTQ | ||||
| NLIGAMEEVP | PDWERASFQQ | GSQASPDLKP | SPQNGATFPS | SGGYGQGSLI | ||||
| ADEESQEFDD | LIFALKTGAG | LSVSDNESGQ | GSQEGGTLTD | SQIVELRRIP | ||||
| IADTHL |
Кодований геном білок за функціями належить до рецепторів, g-білокспряжених рецепторів, білків внутрішньоклітинного сигналінгу. Задіяний у таких біологічних процесах, як альтернативний сплайсинг, поліморфізм. Білок має сайт для зв'язування з іоном кальцію. Локалізований у клітинній мембрані, мембрані.
Література
- McMillan D.R., Kayes-Wandover K.M., Richardson J.A., White P.C. (2002). Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J. Biol. Chem. 277: 785—792. PMID 11606593 DOI:10.1074/jbc.M108929200
- Nagase T., Kikuno R., Ohara O. (2001). Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. DNA Res. 8: 319—327. PMID 11853319 DOI:10.1093/dnares/8.6.319
- Weston M.D., Luijendijk M.W.J., Humphrey K.D., Moeller C., Kimberling W.J. (2004). Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II. Am. J. Hum. Genet. 74: 357—366. PMID 14740321 DOI:10.1086/381685
Примітки
- ↑ Захворювання, генетично пов'язані з ADGRV1 переглянути/редагувати посилання на ВікіДаних.
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:17416 (англ.) . Процитовано 5 вересня 2017.
- ↑ UniProt, Q8WXG9 (англ.) . Процитовано 5 вересня 2017.
Див. також
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