XBP1

XBP1
Ідентифікатори
Символи	XBP1, TREB5, XBP-1, XBP2, TREB-5, X-box binding protein 1
Зовнішні ІД	OMIM: 194355 MGI: 98970 HomoloGene: 3722 GeneCards: XBP1
Пов'язані генетичні захворювання
esophagus squamous cell carcinoma
Онтологія гена Молекулярна функція • estrogen receptor binding • protein homodimerization activity • RNA polymerase II transcription factor binding • protease binding • protein binding • protein kinase binding • sequence-specific DNA binding • enhancer sequence-specific DNA binding • protein heterodimerization activity • chromatin DNA binding • ubiquitin protein ligase binding • DNA binding • core promoter binding • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • identical protein binding Клітинна компонента • гіалоплазма • мембрана • integral component of membrane • nucleoplasm • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • Цитоплазма • Ендоплазматичний ретикулум • клітинне ядро Біологічний процес • positive regulation of MHC class II biosynthetic process • positive regulation of protein phosphorylation • negative regulation of endoplasmic reticulum unfolded protein response • positive regulation of immunoglobulin production • muscle organ development • vascular endothelial growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • Апоптоз • regulation of transcription, DNA-templated • regulation of protein stability • glucose homeostasis • transcription, DNA-templated • cell growth • positive regulation of endothelial cell apoptotic process • response to unfolded protein • fatty acid biosynthetic process • protein transport • positive regulation of TOR signaling • exocrine pancreas development • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • Диференціація клітин • positive regulation of autophagy • cellular response to laminar fluid shear stress • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • positive regulation of B cell differentiation • negative regulation of transcription from RNA polymerase II promoter • cellular response to fluid shear stress • organelle organization • regulation of autophagy • immune response • positive regulation of proteasomal protein catabolic process • positive regulation of plasma cell differentiation • positive regulation of T cell differentiation • positive regulation of endoplasmic reticulum unfolded protein response • positive regulation of histone methylation • lipid metabolism • epithelial cell maturation involved in salivary gland development • positive regulation of protein acetylation • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • Автофагія • multicellular organism development • ATF6-mediated unfolded protein response • IRE1-mediated unfolded protein response • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • epithelial cell maturation • cellular response to oxidative stress • cellular response to vascular endothelial growth factor stimulus • positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter • protein destabilization • cellular response to peptide hormone stimulus • positive regulation of transcription from RNA polymerase II promoter • negative regulation of pathway-restricted SMAD protein phosphorylation • adipose tissue development • positive regulation of vascular associated smooth muscle cell migration • liver development • cellular triglyceride homeostasis • cholesterol homeostasis • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of lactation • cellular response to amino acid stimulus • Ангіогенез • cellular response to glucose starvation • response to insulin-like growth factor stimulus • negative regulation of ERK1 and ERK2 cascade • fatty acid homeostasis • positive regulation of vascular smooth muscle cell proliferation • positive regulation of hepatocyte proliferation • sterol homeostasis • cellular response to interleukin-4 • positive regulation of protein kinase B signaling • ubiquitin-dependent protein catabolic process • positive regulation of fat cell differentiation • negative regulation of apoptotic process • endothelial cell proliferation • transcription from RNA polymerase II promoter • positive regulation of cell proliferation • negative regulation of myotube differentiation • positive regulation of cell migration • endoplasmic reticulum unfolded protein response • cellular response to nutrient • cellular response to insulin stimulus • response to endoplasmic reticulum stress • positive regulation of vascular wound healing • positive regulation of angiogenesis • neuron development • positive regulation of immunoglobulin secretion • cellular response to lipopolysaccharide • cellular response to fructose stimulus • cellular response to glucose stimulus • positive regulation of interleukin-6 secretion • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • cellular response to leukemia inhibitory factor • positive regulation of protein import into nucleus • regulation of cell growth Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	7494	22433
Ensembl	ENSG00000100219	ENSMUSG00000020484
UniProt	P17861	O35426
RefSeq (мРНК)	NM_005080 NM_001079539	NM_001271730 NM_013842
RefSeq (білок)	NP_001073007 NP_005071	NP_001258659 NP_038870
Локус (UCSC)	Хр. 22: 28.79 – 28.8 Mb	Хр. 11: 5.52 – 5.53 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

XBP1 (англ. X-box binding protein 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 22-ї хромосоми. Довжина поліпептидного ланцюга білка становить 261 амінокислот, а молекулярна маса — 28 695.

Послідовність амінокислот

10		20		30		40		50
MVVVAAAPNP		ADGTPKVLLL		SGQPASAAGA		PAGQALPLMV		PAQRGASPEA
ASGGLPQARK		RQRLTHLSPE		EKALRRKLKN		RVAAQTARDR		KKARMSELEQ
QVVDLEEENQ		KLLLENQLLR		EKTHGLVVEN		QELRQRLGMD		ALVAEEEAEA
KGNEVRPVAG		SAESAALRLR		APLQQVQAQL		SPLQNISPWI		LAVLTLQIQS
LISCWAFWTT		WTQSCSSNAL		PQSLPAWRSS		QRSTQKDPVP		YQPPFLCQWG
RHQPSWKPLM		N

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Кодований геном білок за функціями належить до активаторів, білків розвитку, фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, відповідь на стрес, транскрипція, регуляція транскрипції, метаболізм ліпідів, транспорт, транспорт білків, відповідь на порушення конформації білку, ангіогенез, автофагія, біосинтез ліпідів, диференціація клітин, міогенез, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з ДНК. Локалізований у цитоплазмі, ядрі, мембрані, ендоплазматичному ретикулумі.

Література

• Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K. (2001). XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.. Cell 107: 881 — 891.  PubMed DOI:10.1016/S0092-8674(01)00611-0
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504
• Ono S.J., Liou H.C., Davidon R., Strominger J.L., Glimcher L.H. (1991). Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.. Proc. Natl. Acad. Sci. U.S.A. 88: 4309 — 4312.  PubMed DOI:10.1073/pnas.88.10.4309
• Clauss I.M., Chu M., Zhao J.-L., Glimcher L.H. (1996). The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.. Nucleic Acids Res. 24: 1855 — 1864.  PubMed DOI:10.1093/nar/24.10.1855
• Sriburi R., Jackowski S., Mori K., Brewer J.W. (2004). XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.. J. Cell Biol. 167: 35 — 41.  PubMed DOI:10.1083/jcb.200406136
• Yoshida H., Nadanaka S., Sato R., Mori K. (2006). XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells.. Cell Struct. Funct. 31: 117 — 125.  PubMed DOI:10.1247/csf.06016

Див. також

• Хромосома 22